{"id":205762,"date":"2025-02-06T16:16:21","date_gmt":"2025-02-06T22:16:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/scientists-recode-the-genome-for-programmable-synthetic-proteins"},"modified":"2025-02-06T16:16:21","modified_gmt":"2025-02-06T22:16:21","slug":"scientists-recode-the-genome-for-programmable-synthetic-proteins","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/scientists-recode-the-genome-for-programmable-synthetic-proteins","title":{"rendered":"Scientists recode the genome for programmable synthetic proteins"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-recode-the-genome-for-programmable-synthetic-proteins2.jpg\"><\/a><\/p>\n<p>Synthetic biologists from Yale were able to re-write the genetic code of an organism\u2014a novel genomically recoded organism (GRO) with one stop codon\u2014using a cellular platform that they developed enabling the production of new classes of synthetic proteins. These synthetic proteins, researchers say, offer the promise of innumerable medical and industrial applications that can benefit society and human health.<\/p>\n<p>The creation of the landmark GRO, known as \u201cOchre\u201d\u2014which fully compresses redundant, or \u201cdegenerate\u201d codons, into a single codon\u2014is described in a new study <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08501-x\" target=\"_blank\">published<\/a> in the journal <i>Nature<\/i>. A codon is a sequence of three nucleotides in DNA or RNA that codes for a specific amino acid, which serves as the biochemical building blocks for proteins.<\/p>\n<p>\u201cThis research allows us to ask fundamental questions about the malleability of genetic codes,\u201d said Farren Isaacs, professor of molecular, cellular and <a href=\"https:\/\/phys.org\/tags\/developmental+biology\/\" rel=\"tag\" class=\"\">developmental biology<\/a> at Yale School of Medicine and of biomedical engineering at Yale\u2019s Faculty of Arts and <i>Science<\/i>s, who is co-senior author of the paper. \u201cIt also demonstrates the ability to engineer the genetic code to endow multi-functionality into proteins and usher in a new era of programmable biotherapeutics and biomaterials.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Synthetic biologists from Yale were able to re-write the genetic code of an organism\u2014a novel genomically recoded organism (GRO) with one stop codon\u2014using a cellular platform that they developed enabling the production of new classes of synthetic proteins. These synthetic proteins, researchers say, offer the promise of innumerable medical and industrial applications that can benefit [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,19,412,1495],"tags":[],"class_list":["post-205762","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-chemistry","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=205762"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205762\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=205762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=205762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=205762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}