{"id":205511,"date":"2025-02-04T14:18:40","date_gmt":"2025-02-04T20:18:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/spermidine-metabolism-regulates-leukemia-stem-and-progenitor-cell-function-through-kat7-expression-in-patient-derived-mouse-models"},"modified":"2025-02-04T14:18:40","modified_gmt":"2025-02-04T20:18:40","slug":"spermidine-metabolism-regulates-leukemia-stem-and-progenitor-cell-function-through-kat7-expression-in-patient-derived-mouse-models","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/spermidine-metabolism-regulates-leukemia-stem-and-progenitor-cell-function-through-kat7-expression-in-patient-derived-mouse-models","title":{"rendered":"Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/spermidine-metabolism-regulates-leukemia-stem-and-progenitor-cell-function-through-kat7-expression-in-patient-derived-mouse-models2.jpg\"><\/a><\/p>\n<p>A metabolomics study pinpointed the differences between leukemia stem cells (LSCs) and their normal counterparts, and suggests elevated levels of spermidine are a signature and a targetable weakness in LSCs.<\/p>\n<hr>\n<p>Spermidine is essential for the function of leukemia stem and progenitor cells through the regulation of KAT7 expression.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A metabolomics study pinpointed the differences between leukemia stem cells (LSCs) and their normal counterparts, and suggests elevated levels of spermidine are a signature and a targetable weakness in LSCs. Spermidine is essential for the function of leukemia stem and progenitor cells through the regulation of KAT7 expression.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-205511","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=205511"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205511\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=205511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=205511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=205511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}