{"id":205411,"date":"2025-02-03T23:43:24","date_gmt":"2025-02-04T05:43:24","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/mrna-based-drugs-successfully-delivered-to-intestine-without-passing-through-the-liver"},"modified":"2025-02-03T23:43:24","modified_gmt":"2025-02-04T05:43:24","slug":"mrna-based-drugs-successfully-delivered-to-intestine-without-passing-through-the-liver","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/mrna-based-drugs-successfully-delivered-to-intestine-without-passing-through-the-liver","title":{"rendered":"MRNA-based drugs successfully delivered to intestine\u2014without passing through the liver"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mrna-based-drugs-successfully-delivered-to-intestine-without-passing-through-the-liver2.jpg\"><\/a><\/p>\n<p>Researchers at Tel Aviv University have achieved a breakthrough in drug delivery: they have successfully transported lipid nanoparticles encapsulating messenger RNA (mRNA) to the immune system of the small and large intestines\u2014bypassing the liver upon systemic administration. By simply altering the composition of the nanoparticles, the researchers demonstrated that mRNA-based drugs can be directed straight to target cells, avoiding the liver.<\/p>\n<p>The Tel Aviv University study was led by post-doctoral fellow Dr. Riccardo Rampado together with Vice President for R&amp;D Prof. Dan Peer, a pioneer in the development of mRNA therapeutics and Director of the Laboratory of Precision Nano-Medicine at the Shmunis School of Biomedical and Cancer Research. The study was published on the cover of the journal <a href=\"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202408744\" target=\"_blank\"><i>Advanced Science<\/i><\/a>.<\/p>\n<p>\u201cEverything injected into the bloodstream eventually ends up in the liver\u2014that\u2019s just how our anatomy works,\u201d explains Prof. Peer. \u201cThis poses two challenges. First, drugs intended to target specific cells in particular organs may be toxic to the liver. Second, we don\u2019t want drugs to get \u2018stuck\u2019 in the liver.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Tel Aviv University have achieved a breakthrough in drug delivery: they have successfully transported lipid nanoparticles encapsulating messenger RNA (mRNA) to the immune system of the small and large intestines\u2014bypassing the liver upon systemic administration. By simply altering the composition of the nanoparticles, the researchers demonstrated that mRNA-based drugs can be directed straight [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4],"tags":[],"class_list":["post-205411","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205411","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=205411"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205411\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=205411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=205411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=205411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}