{"id":205363,"date":"2025-02-03T13:45:46","date_gmt":"2025-02-03T19:45:46","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/complex-model-of-molecular-wear-and-tear-shines-light-on-how-proteins-age"},"modified":"2025-02-03T13:45:46","modified_gmt":"2025-02-03T19:45:46","slug":"complex-model-of-molecular-wear-and-tear-shines-light-on-how-proteins-age","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/complex-model-of-molecular-wear-and-tear-shines-light-on-how-proteins-age","title":{"rendered":"Complex model of molecular \u2018wear-and-tear\u2019 shines light on how proteins age"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/complex-model-of-molecular-wear-and-tear-shines-light-on-how-proteins-age.jpg\"><\/a><\/p>\n<p>Chromatin, the mix of DNA and protein that houses each cell\u2019s genome, is more resilient to aging than previously thought, suggests a study <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.4c14136\" target=\"_blank\">published<\/a> in the <i>Journal of the American Chemical Society<\/i> by researchers at King\u2019s College London.<\/p>\n<p>Scientists believe this may reveal how the body can cope with the inevitable \u201cwear-and-tear\u201d of aging and where it may be more vulnerable to its effects, laying the groundwork for future anti-aging treatments throughout the body.<\/p>\n<p>Proteins, much like the rest of the body, change when aging. This is especially the case for the <a href=\"https:\/\/phys.org\/tags\/histone+proteins\/\" rel=\"tag\" class=\"\">histone proteins<\/a> that make up <a href=\"https:\/\/phys.org\/tags\/chromatin\/\" rel=\"tag\" class=\"\">chromatin<\/a>, which may \u201clive\u201d for ~100 days before being replenished and replaced. During their lifetime, proteins are stretched and distorted, or experience processes that are similar to rusting. This damage results in naturally occurring <a href=\"https:\/\/phys.org\/tags\/chemical+changes\/\" rel=\"tag\" class=\"\">chemical changes<\/a> to the protein called post-translational modifications, or PTMs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chromatin, the mix of DNA and protein that houses each cell\u2019s genome, is more resilient to aging than previously thought, suggests a study published in the Journal of the American Chemical Society by researchers at King\u2019s College London. Scientists believe this may reveal how the body can cope with the inevitable \u201cwear-and-tear\u201d of aging and [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,269],"tags":[],"class_list":["post-205363","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205363","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=205363"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205363\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=205363"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=205363"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=205363"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}