{"id":205217,"date":"2025-02-02T02:18:11","date_gmt":"2025-02-02T08:18:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/trim28-dependent-developmental-heterogeneity-determines-cancer-susceptibility-through-distinct-epigenetic-states"},"modified":"2025-02-02T02:18:11","modified_gmt":"2025-02-02T08:18:11","slug":"trim28-dependent-developmental-heterogeneity-determines-cancer-susceptibility-through-distinct-epigenetic-states","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/trim28-dependent-developmental-heterogeneity-determines-cancer-susceptibility-through-distinct-epigenetic-states","title":{"rendered":"TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/trim28-dependent-developmental-heterogeneity-determines-cancer-susceptibility-through-distinct-epigenetic-states.jpg\"><\/a><\/p>\n<p>Panzeri <i>et al.<\/i> use a <i>Trim28 <\/i>+\/D9 mouse model with intrinsic developmental heterogeneity to show that \u2018heavy\u2019 and \u2018light\u2019 developmental morphs exhibit different timing, type and severity of cancer, linked to a relevant DNA hypomethylation signature.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Panzeri et al. use a Trim28 +\/D9 mouse model with intrinsic developmental heterogeneity to show that \u2018heavy\u2019 and \u2018light\u2019 developmental morphs exhibit different timing, type and severity of cancer, linked to a relevant DNA hypomethylation signature.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-205217","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=205217"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205217\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=205217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=205217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=205217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}