{"id":205133,"date":"2025-02-01T01:23:49","date_gmt":"2025-02-01T07:23:49","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/02\/next-gen-cas12a-system-enables-precise-single-and-multiplexed-gene-editing-in-cancer"},"modified":"2025-02-01T01:23:49","modified_gmt":"2025-02-01T07:23:49","slug":"next-gen-cas12a-system-enables-precise-single-and-multiplexed-gene-editing-in-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/02\/next-gen-cas12a-system-enables-precise-single-and-multiplexed-gene-editing-in-cancer","title":{"rendered":"Next-Gen Cas12a System Enables Precise Single and Multiplexed Gene Editing in Cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/next-gen-cas12a-system-enables-precise-single-and-multiplexed-gene-editing-in-cancer.jpg\"><\/a><\/p>\n<p>Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice. Their work establishes a next-generation gene-editing tool that enhances genetic manipulation for cancer and medical research in a preclinical model.<\/p>\n<p>The study, \u201c<a href=\"https:\/\/www.nature.com\/articles\/s41467-025-56282-2\">Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening<\/a>,\u201d was published in <em>Nature Communications<\/em><em>.<\/em><\/p>\n<p>\u201cThis is the first time Cas12a has been used in preclinical models, which will greatly advance our genome engineering capabilities,\u201d said co-author Eddie La Marca, PhD, a postdoctoral researcher at the Olivia Newton-John Cancer Research Institute (ONJCRI) in Australia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice. Their work establishes a next-generation gene-editing tool that enhances genetic manipulation for cancer and medical research in a preclinical model. The study, \u201cAdvancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening,\u201d was published in Nature Communications. \u201cThis [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-205133","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=205133"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/205133\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=205133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=205133"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=205133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}