{"id":204923,"date":"2025-01-30T09:33:19","date_gmt":"2025-01-30T15:33:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/01\/cancer-fighting-virus-t-vec-helps-shrink-tough-to-treat-skin-tumors"},"modified":"2025-01-30T09:33:19","modified_gmt":"2025-01-30T15:33:19","slug":"cancer-fighting-virus-t-vec-helps-shrink-tough-to-treat-skin-tumors","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/01\/cancer-fighting-virus-t-vec-helps-shrink-tough-to-treat-skin-tumors","title":{"rendered":"Cancer-fighting virus T-VEC helps shrink tough-to-treat skin tumors"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/cancer-fighting-virus-t-vec-helps-shrink-tough-to-treat-skin-tumors.jpg\"><\/a><\/p>\n<p>Neoadjuvant therapy with hedgehog inhibitors has an overall response rate (ORR) of 71%, but adverse events (AEs) like fatigue, muscle cramps, dysgeusia, and hair loss often lead to discontinuation and low compliance.<\/p>\n<p>OVs represent a class of intratumoral therapeutics that might be a safe and effective neoadjuvant therapy for difficult-to-resect BCCs.<\/p>\n<p>Talimogene laherparepvec (T-VEC) is an OV, a genetically engineered herpes simplex virus 1 (HSV1), approved for treating injectable, unresectable <a href=\"https:\/\/www.news-medical.net\/health\/What-are-Melanomas.aspx\" class=\"\">melanoma<\/a> lesions in the United States and Europe. T-VEC has a dual mode of action and can alter the tumor microenvironment (TME) by activating adaptive and innate immunity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neoadjuvant therapy with hedgehog inhibitors has an overall response rate (ORR) of 71%, but adverse events (AEs) like fatigue, muscle cramps, dysgeusia, and hair loss often lead to discontinuation and low compliance. OVs represent a class of intratumoral therapeutics that might be a safe and effective neoadjuvant therapy for difficult-to-resect BCCs. Talimogene laherparepvec (T-VEC) is [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-204923","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/204923","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=204923"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/204923\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=204923"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=204923"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=204923"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}