{"id":204811,"date":"2025-01-29T03:22:12","date_gmt":"2025-01-29T09:22:12","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/01\/maintaining-telomeres-extends-lifespan-in-mice"},"modified":"2025-01-29T03:22:12","modified_gmt":"2025-01-29T09:22:12","slug":"maintaining-telomeres-extends-lifespan-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/01\/maintaining-telomeres-extends-lifespan-in-mice","title":{"rendered":"Maintaining Telomeres Extends Lifespan in Mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/maintaining-telomeres-extends-lifespan-in-mice.jpg\"><\/a><\/p>\n<p>A recent study has found that the overexpression of telomerase reverse transcriptase (TERT), which is a subunit of telomerase, an enzyme essential for telomere maintenance, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39660787\/\">leads to lifespan extension in mice without significant side effects<\/a> [1].<\/p>\n<p><b><b>Protecting DNA<\/b><\/b><\/p>\n<p><a href=\"https:\/\/www.lifespan.io\/topic\/telomere-attrition\/\">Telomere shortening<\/a> is a well-known <a href=\"https:\/\/www.lifespan.io\/topic\/aging\/\">hallmark of aging<\/a>. Telomeres are protective DNA sequences at the ends of the chromosomes. In most human cells, they become shorter with each division.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent study has found that the overexpression of telomerase reverse transcriptase (TERT), which is a subunit of telomerase, an enzyme essential for telomere maintenance, leads to lifespan extension in mice without significant side effects [1]. Protecting DNA Telomere shortening is a well-known hallmark of aging. Telomeres are protective DNA sequences at the ends of [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-204811","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/204811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=204811"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/204811\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=204811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=204811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=204811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}