{"id":204132,"date":"2025-01-20T14:30:56","date_gmt":"2025-01-20T20:30:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/01\/parkinsons-discovery-suggests-we-could-already-have-an-fda-approved-treatment"},"modified":"2025-01-20T14:30:56","modified_gmt":"2025-01-20T20:30:56","slug":"parkinsons-discovery-suggests-we-could-already-have-an-fda-approved-treatment","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/01\/parkinsons-discovery-suggests-we-could-already-have-an-fda-approved-treatment","title":{"rendered":"Parkinson\u2019s Discovery Suggests We Could Already Have an FDA-Approved Treatment"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/parkinsons-discovery-suggests-we-could-already-have-an-fda-approved-treatment2.jpg\"><\/a><\/p>\n<p>Researchers have discovered how a cell surface protein called Aplp1 can play a role in spreading material responsible for <a href=\"https:\/\/www.sciencealert.com\/go\/IYl\" class=\"\" rel=\"nofollow\" target=\"_self\">Parkinson\u2019s<\/a> disease from cell-to-cell in the brain.<\/p>\n<p>Promisingly, an FDA-approved <a href=\"https:\/\/www.sciencealert.com\/cancer\" class=\"\" rel=\"nofollow\" target=\"_self\">cancer<\/a> drug that targets another protein called <a href=\"https:\/\/en.wikipedia.org\/wiki\/Lymphocyte-activation_gene_3\">Lag3<\/a> \u2013 which interacts with <a href=\"https:\/\/en.wikipedia.org\/wiki\/APLP1\">Aplp1<\/a> \u2013 blocks the spread in mice, suggesting a potential therapy may already exist.<\/p>\n<p>In a <a href=\"https:\/\/link.springer.com\/article\/10.1038\/s41467-024-49016-3\">paper published last year<\/a>, an international team of scientists describes how the two proteins work together to help harmful <a href=\"https:\/\/en.wikipedia.org\/wiki\/Alpha-synuclein\">alpha-synuclein<\/a> protein clumps get into brain cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have discovered how a cell surface protein called Aplp1 can play a role in spreading material responsible for Parkinson\u2019s disease from cell-to-cell in the brain. Promisingly, an FDA-approved cancer drug that targets another protein called Lag3 \u2013 which interacts with Aplp1 \u2013 blocks the spread in mice, suggesting a potential therapy may already exist. [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-204132","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/204132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=204132"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/204132\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=204132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=204132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=204132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}