{"id":203328,"date":"2025-01-08T02:38:24","date_gmt":"2025-01-08T08:38:24","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/01\/ai-technique-generates-clear-images-of-thick-biological-samples-without-additional-hardware"},"modified":"2025-01-08T02:38:24","modified_gmt":"2025-01-08T08:38:24","slug":"ai-technique-generates-clear-images-of-thick-biological-samples-without-additional-hardware","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/01\/ai-technique-generates-clear-images-of-thick-biological-samples-without-additional-hardware","title":{"rendered":"AI technique generates clear images of thick biological samples without additional hardware"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ai-technique-generates-clear-images-of-thick-biological-samples-without-additional-hardware2.jpg\"><\/a><\/p>\n<p>Depth degradation is a problem biologists know all too well: The deeper you look into a sample, the fuzzier the image becomes. A worm embryo or a piece of tissue may only be tens of microns thick, but the bending of light causes microscopy images to lose their sharpness as the instruments peer beyond the top layer.<\/p>\n<p>To deal with this problem, microscopists add technology to existing microscopes to cancel out these distortions. But this technique, called <a href=\"https:\/\/phys.org\/tags\/adaptive+optics\/\" rel=\"tag\" class=\"\">adaptive optics<\/a>, requires time, money, and expertise, making it available to relatively few biology labs.<\/p>\n<p>Now, researchers at HHMI\u2019s Janelia Research Campus and collaborators have developed a way to make a similar correction, but without using adaptive optics, adding additional hardware, or taking more images. A team from the Shroff Lab has developed a new AI method that produces sharp microscopy images throughout a thick biological sample.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Depth degradation is a problem biologists know all too well: The deeper you look into a sample, the fuzzier the image becomes. A worm embryo or a piece of tissue may only be tens of microns thick, but the bending of light causes microscopy images to lose their sharpness as the instruments peer beyond the [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,6],"tags":[],"class_list":["post-203328","post","type-post","status-publish","format-standard","hentry","category-biological","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/203328","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=203328"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/203328\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=203328"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=203328"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=203328"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}