{"id":203198,"date":"2025-01-06T15:04:59","date_gmt":"2025-01-06T21:04:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/01\/selective-silencing-new-research-challenges-textbook-principle-of-genetics"},"modified":"2025-01-06T15:04:59","modified_gmt":"2025-01-06T21:04:59","slug":"selective-silencing-new-research-challenges-textbook-principle-of-genetics","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/01\/selective-silencing-new-research-challenges-textbook-principle-of-genetics","title":{"rendered":"\u201cSelective Silencing\u201d: New Research Challenges Textbook Principle of Genetics"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/selective-silencing-new-research-challenges-textbook-principle-of-genetics2.jpg\"><\/a><\/p>\n<p><b>Why it matters<\/b><\/p>\n<p>The new study explains a longstanding puzzle in medicine: why do some people who\u2019ve inherited a disease-causing mutation experience fewer symptoms than others with the same mutation? \u201cIn many diseases, we\u2019ll see that 90% of people who carry a mutation are sick, but 10% who carry the mutation don\u2019t get sick at all,\u201d says Bogunovic, a scientist who studies children with rare immunological disorders at Columbia University Irving Medical Center.<\/p>\n<p>Enlisting an international team of collaborators, the researchers looked at several families with different genetic disorders affecting their immune systems. In each case, the disease-causing copy was more likely to be active in sick patients and suppressed in healthy relatives who had inherited the same genes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Why it matters The new study explains a longstanding puzzle in medicine: why do some people who\u2019ve inherited a disease-causing mutation experience fewer symptoms than others with the same mutation? \u201cIn many diseases, we\u2019ll see that 90% of people who carry a mutation are sick, but 10% who carry the mutation don\u2019t get sick at [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-203198","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/203198","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=203198"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/203198\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=203198"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=203198"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=203198"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}