{"id":203082,"date":"2025-01-04T11:31:38","date_gmt":"2025-01-04T17:31:38","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/01\/study-reveals-key-alzheimers-pathway-and-blocking-it-reverses-symptoms-in-mice"},"modified":"2025-01-04T11:31:38","modified_gmt":"2025-01-04T17:31:38","slug":"study-reveals-key-alzheimers-pathway-and-blocking-it-reverses-symptoms-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/01\/study-reveals-key-alzheimers-pathway-and-blocking-it-reverses-symptoms-in-mice","title":{"rendered":"Study Reveals Key Alzheimer\u2019s Pathway \u2014 And Blocking It Reverses Symptoms in Mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/study-reveals-key-alzheimers-pathway-and-blocking-it-reverses-symptoms-in-mice2.jpg\"><\/a><\/p>\n<p>A sequence of stress signals among specialized clean-up cells in the brain could at last reveal why some immune responses can cause significant nerve degeneration that results in the loss of memory, judgement, and awareness behind <a href=\"https:\/\/www.sciencealert.com\/go\/IaO\" class=\"\" rel=\"nofollow\" target=\"_self\">Alzheimer\u2019s<\/a> disease.<\/p>\n<p>Blocking this pathway in mouse brains modeled on Alzheimer\u2019s prevented damage to their synapse connections and reduced the buildup of potentially toxic <a href=\"https:\/\/www.sciencealert.com\/alzheimers-study-reveals-how-toxic-clumps-warp-neurons-at-their-core\">tau proteins<\/a> \u2013 both hallmarks of the condition.<\/p>\n<p>The researchers, led by a team from the City University of New York (CUNY), believe this pathway \u2013 called the integrated stress response (ISR) \u2013 causes brain immune cells called <a href=\"https:\/\/en.wikipedia.org\/wiki\/Microglia\">microglia<\/a> to go \u2018dark\u2019 and start damaging rather than benefiting the brain.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A sequence of stress signals among specialized clean-up cells in the brain could at last reveal why some immune responses can cause significant nerve degeneration that results in the loss of memory, judgement, and awareness behind Alzheimer\u2019s disease. Blocking this pathway in mouse brains modeled on Alzheimer\u2019s prevented damage to their synapse connections and reduced [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-203082","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/203082","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=203082"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/203082\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=203082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=203082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=203082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}