{"id":202606,"date":"2024-12-28T03:02:22","date_gmt":"2024-12-28T09:02:22","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/12\/brain-tumor-organoids-accurately-model-patient-response-to-car-t-cell-therapy"},"modified":"2024-12-28T03:02:22","modified_gmt":"2024-12-28T09:02:22","slug":"brain-tumor-organoids-accurately-model-patient-response-to-car-t-cell-therapy","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/12\/brain-tumor-organoids-accurately-model-patient-response-to-car-t-cell-therapy","title":{"rendered":"Brain tumor organoids accurately model patient response to CAR T cell therapy"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/brain-tumor-organoids-accurately-model-patient-response-to-car-t-cell-therapy2.jpg\"><\/a><\/p>\n<p>For the first time, researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient\u2019s response to CAR T cell therapy in real time. The organoid\u2019s response to therapy mirrored the response of the actual tumor in the patient\u2019s brain. That is, if the tumor-derived organoid shrunk after treatment, so did the patient\u2019s actual tumor, according to new research from the Perelman School of Medicine, published in Cell Stem Cell.<\/p>\n<hr>\n<p>Lab-grown tumors respond to cell therapy the same as tumors in the patients\u2019 brains, according to researchers at Penn Medicine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>For the first time, researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient\u2019s response to CAR T cell therapy in real time. The organoid\u2019s response to therapy mirrored the response of the actual tumor in the patient\u2019s brain. That is, if the tumor-derived organoid shrunk after treatment, [\u2026]<\/p>\n","protected":false},"author":534,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-202606","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/202606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/534"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=202606"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/202606\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=202606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=202606"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=202606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}