{"id":202407,"date":"2024-12-25T20:48:20","date_gmt":"2024-12-26T02:48:20","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/12\/nanovaccine-derived-from-pre-chemotherapy-tumors-combats-multiple-tumors-in-mice"},"modified":"2024-12-25T20:48:20","modified_gmt":"2024-12-26T02:48:20","slug":"nanovaccine-derived-from-pre-chemotherapy-tumors-combats-multiple-tumors-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/12\/nanovaccine-derived-from-pre-chemotherapy-tumors-combats-multiple-tumors-in-mice","title":{"rendered":"Nanovaccine derived from pre-chemotherapy tumors combats multiple tumors in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nanovaccine-derived-from-pre-chemotherapy-tumors-combats-multiple-tumors-in-mice.jpg\"><\/a><\/p>\n<p>A research team led by Prof. Nie Guangjun from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS) and collaborators have demonstrated a tumor membrane antigens-based nanovaccine derived from liposomal doxorubicin treated tumor tissues, which is efficacious in inducing a potent immunological defense against tumors. The study is <a href=\"https:\/\/www.cell.com\/cell-reports-medicine\/fulltext\/S2666-3791(24)00648-7\" target=\"_blank\">published<\/a> online in Cell Reports Medicine.<\/p>\n<p>For solid tumor surgeries, challenges remain in postoperative tumor recurrence and metastasis. The correlation between postoperative tumor recurrence and metastasis and the host\u2019s antitumor immune status is well-established. Personalized cancer vaccines, using the patient\u2019s own tumor as an antigen source, stimulate a robust immune response that is efficacious in eliminating residual neoplastic foci following <a href=\"https:\/\/phys.org\/tags\/surgical+intervention\/\" rel=\"tag\" class=\"\">surgical intervention<\/a> as well as in targeting metastatic lesions at a distance, significantly reducing the risk of postoperative tumor recurrence and metastasis.<\/p>\n<p>The efficacy of autologous tumor <a href=\"https:\/\/phys.org\/tags\/cells\/\" rel=\"tag\" class=\"\">cells<\/a> in <a href=\"https:\/\/phys.org\/tags\/clinical+trials\/\" rel=\"tag\" class=\"\">clinical trials<\/a> has been limited by their weak immunogenicity. The tumor <a href=\"https:\/\/phys.org\/tags\/membrane\/\" rel=\"tag\" class=\"\">membrane<\/a> contains tumor-presented antigens and associated antigens, which can be developed into a personalized antigen library that more accurately reflects the expression of tumor antigens. Vaccines based on autologous tumor cell membrane antigens have been developed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team led by Prof. Nie Guangjun from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS) and collaborators have demonstrated a tumor membrane antigens-based nanovaccine derived from liposomal doxorubicin treated tumor tissues, which is efficacious in inducing a potent immunological defense against tumors. The study is published [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4],"tags":[],"class_list":["post-202407","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/202407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=202407"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/202407\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=202407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=202407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=202407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}