{"id":202050,"date":"2024-12-21T00:29:47","date_gmt":"2024-12-21T06:29:47","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/12\/ai-expedites-motor-neuron-analysis-and-screening-in-als-research"},"modified":"2024-12-21T00:29:47","modified_gmt":"2024-12-21T06:29:47","slug":"ai-expedites-motor-neuron-analysis-and-screening-in-als-research","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/12\/ai-expedites-motor-neuron-analysis-and-screening-in-als-research","title":{"rendered":"AI Expedites Motor Neuron Analysis and Screening in ALS Research"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ai-expedites-motor-neuron-analysis-and-screening-in-als-research2.png\"><\/a><\/p>\n<p>To create cultured LMNs that replicate ALS neuron physiology and function, the Japanese team combined a small molecule-based approach with transcription factor transduction. The researchers achieved 80% induction efficiency of LMNs within just two weeks compared with conventional methods.<\/p>\n<p>The resulting LMNs were found to have replicated ALS-specific pathologies, such as the abnormal aggregation of TDP-43 and FUS proteins. The team confirmed functionality of the LMNs using a multi-electrode array (MEA) system to measure firing activity and network activity, which were found to be similar to mature neurons.<\/p>\n<p>Further analysis of the cultured LMNs showed that in addition to maintaining ALS cellular markers, the LMNs had reduced survival rates compared with healthy cells, mimicking ALS motor neuron responses.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>To create cultured LMNs that replicate ALS neuron physiology and function, the Japanese team combined a small molecule-based approach with transcription factor transduction. The researchers achieved 80% induction efficiency of LMNs within just two weeks compared with conventional methods. The resulting LMNs were found to have replicated ALS-specific pathologies, such as the abnormal aggregation of [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-202050","post","type-post","status-publish","format-standard","hentry","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/202050","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=202050"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/202050\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=202050"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=202050"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=202050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}