{"id":201565,"date":"2024-12-13T22:05:48","date_gmt":"2024-12-14T04:05:48","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/12\/drug-screening-platform-identifies-compound-for-reinvigorating-exhausted-car-t-cells"},"modified":"2024-12-13T22:05:48","modified_gmt":"2024-12-14T04:05:48","slug":"drug-screening-platform-identifies-compound-for-reinvigorating-exhausted-car-t-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/12\/drug-screening-platform-identifies-compound-for-reinvigorating-exhausted-car-t-cells","title":{"rendered":"Drug screening platform identifies compound for reinvigorating exhausted CAR-T cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/drug-screening-platform-identifies-compound-for-reinvigorating-exhausted-car-t-cells.jpg\"><\/a><\/p>\n<p>A research team led by Prof. Wang Haoyi from the Institute of Zoology (IOZ) of the Chinese Academy of Sciences has developed a chimeric antigen receptor T (CAR-T) cell exhaustion model and a functional screening platform for identifying compounds that can rejuvenate exhausted T cells.<\/p>\n<p>Using this innovative platform, the team identified the small-molecule compound miltefosine, which significantly enhances the tumor-killing activity of CAR-T cells. This study was <a href=\"https:\/\/doi.org\/10.1016\/j.xcrm.2024.101869\" target=\"_blank\">published<\/a> in <i>Cell Reports Medicine<\/i> on December 9.<\/p>\n<p>T cell exhaustion is a differentiation state that arises when T cells are exposed to persistent antigen stimulation. This state is characterized by a progressive loss of effector functions, sustained expression of inhibitory receptors, impaired proliferation, and compromised mitochondrial respiration and glycolysis capacity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team led by Prof. Wang Haoyi from the Institute of Zoology (IOZ) of the Chinese Academy of Sciences has developed a chimeric antigen receptor T (CAR-T) cell exhaustion model and a functional screening platform for identifying compounds that can rejuvenate exhausted T cells. Using this innovative platform, the team identified the small-molecule compound [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1522],"tags":[],"class_list":["post-201565","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-innovation"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/201565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=201565"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/201565\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=201565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=201565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=201565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}