{"id":201544,"date":"2024-12-13T12:26:35","date_gmt":"2024-12-13T18:26:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/12\/ssri-antidepressants-may-cause-fewer-side-effects-when-targeted-to-the-gut"},"modified":"2024-12-13T12:26:35","modified_gmt":"2024-12-13T18:26:35","slug":"ssri-antidepressants-may-cause-fewer-side-effects-when-targeted-to-the-gut","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/12\/ssri-antidepressants-may-cause-fewer-side-effects-when-targeted-to-the-gut","title":{"rendered":"SSRI Antidepressants May Cause Fewer Side Effects When Targeted to the Gut"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/ssri-antidepressants-may-cause-fewer-side-effects-when-targeted-to-the-gut.jpg\"><\/a><\/p>\n<p>The use of antidepressants during pregnancy significantly increased the risk of a child experiencing functional constipation\u2014a common DGBI that may be painful\u2014during their first year of life. \u201cAfter adjusting for covariates, SSRI\/SNRI exposure was associated with an over 3-fold increased risk for functional constipation,\u201d the investigators wrote.<\/p>\n<p>\u201cWe found that, at the age of one, 63% of children exposed to antidepressants during pregnancy experienced constipation, compared with 31% of children whose mothers did not take medication,\u201d said study co-author Larissa Takser, MD, professor of pediatrics at the Universit\u00e9 de Sherbrooke in Qu\u00e9bec. \u201cThis finding suggests a potential connection between serotonin levels in utero and gut development, and opens new doors to examine SSRI properties not previously studied.\u201d<\/p>\n<p>The investigators\u2019 collective findings point to a promising avenue of future studies: the gut epithelium as a new and potentially safer target for treating mood disorders, particularly for pregnant women. \u201cTogether, these data define a novel potential mechanism for gut-brain communication and identify intestinal epithelial 5-HT as a new and potentially safer therapeutic target for mood regulation,\u201d the authors stated.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The use of antidepressants during pregnancy significantly increased the risk of a child experiencing functional constipation\u2014a common DGBI that may be painful\u2014during their first year of life. \u201cAfter adjusting for covariates, SSRI\/SNRI exposure was associated with an over 3-fold increased risk for functional constipation,\u201d the investigators wrote. \u201cWe found that, at the age of one, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,47],"tags":[],"class_list":["post-201544","post","type-post","status-publish","format-standard","hentry","category-futurism","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/201544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=201544"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/201544\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=201544"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=201544"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=201544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}