{"id":200975,"date":"2024-12-07T15:34:15","date_gmt":"2024-12-07T21:34:15","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/12\/a-sickle-cell-first-base-editing-a-new-form-of-gene-therapy-leaves-patient-feeling-more-than-fine"},"modified":"2024-12-07T15:34:15","modified_gmt":"2024-12-07T21:34:15","slug":"a-sickle-cell-first-base-editing-a-new-form-of-gene-therapy-leaves-patient-feeling-more-than-fine","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/12\/a-sickle-cell-first-base-editing-a-new-form-of-gene-therapy-leaves-patient-feeling-more-than-fine","title":{"rendered":"A sickle cell first: Base editing, a new form of gene therapy, leaves patient feeling \u2018more than fine\u2019"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/0W-_BmrdH-M?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Though he doesn\u2019t remember it, Branden Baptiste had his first sickle cell crisis at age 2. Through elementary school, he was in and out of the hospital with pain episodes, not knowing why. As he got older, he learned he had sickle cell disease. His red blood cells were forming sickle shapes and getting stuck in his blood stream, preventing oxygen from reaching his tissues.<\/p>\n<p>\u201cSickle cell disease has a broad spectrum of severity, and the severity and frequency of complications can wax and wane,\u201d says Matthew Heeney, MD, Branden\u2019s long-time hematologist at Boston Children\u2019s Hospital.<\/p>\n<p>\u201cUnfortunately, Branden was quickly acquiring many of the chronic complications of sickle cell disease, including organ dysfunction affecting his kidneys, lungs, joints, and eyes.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Though he doesn\u2019t remember it, Branden Baptiste had his first sickle cell crisis at age 2. Through elementary school, he was in and out of the hospital with pain episodes, not knowing why. As he got older, he learned he had sickle cell disease. His red blood cells were forming sickle shapes and getting stuck [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-200975","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/200975","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=200975"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/200975\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=200975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=200975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=200975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}