{"id":200938,"date":"2024-12-07T05:25:11","date_gmt":"2024-12-07T11:25:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/12\/network-based-analyses-uncover-how-neuroinflammation-causing-microglia-in-alzheimers-disease-form"},"modified":"2024-12-07T05:25:11","modified_gmt":"2024-12-07T11:25:11","slug":"network-based-analyses-uncover-how-neuroinflammation-causing-microglia-in-alzheimers-disease-form","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/12\/network-based-analyses-uncover-how-neuroinflammation-causing-microglia-in-alzheimers-disease-form","title":{"rendered":"Network-based analyses uncover how neuroinflammation-causing microglia in Alzheimer\u2019s disease form"},"content":{"rendered":"

<\/a><\/p>\n

Cleveland Clinic Genome Center researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer\u2019s disease. The study, published<\/a> in the journal Alzheimer\u2019s & Dementia, also integrates drug databases with real-world patient data to identify FDA-approved drugs that may be repurposed to target disease-associated microglia in Alzheimer\u2019s disease without affecting the healthy type.<\/p>\n

The researchers, led by study corresponding author Feixiong Cheng, Ph.D., hope their unique approach of integrating genetic, chemical and human health data to identify drug targets<\/a> and corresponding drugs will inspire other scientists to take similar approaches in their own research.<\/p>\n

Microglia are specialized immune cells<\/a> that patrol our brains, seeking and responding to tissue damage and external threats like bacteria and viruses. Different types of microglial cells use different methods to keep the brain safe. Some may cause neuroinflammation\u2014inflammation in the brain\u2014to fight invaders or kickstart the repair process in damaged cells. Others may work to \u201ceat\u201d dangerous substances in the brain, and clean up damage and debris. However, during Alzheimer\u2019s disease, new types of microglia can form that promote disease progression<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cleveland Clinic Genome Center researchers have unraveled how immune cells called microglia can transform and drive harmful processes like neuroinflammation in Alzheimer\u2019s disease. The study, published in the journal Alzheimer\u2019s & Dementia, also integrates drug databases with real-world patient data to identify FDA-approved drugs that may be repurposed to target disease-associated microglia in Alzheimer\u2019s disease [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,412,1495,47],"tags":[],"class_list":["post-200938","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-genetics","category-health","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/200938","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=200938"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/200938\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=200938"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=200938"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=200938"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}