{"id":200499,"date":"2024-11-30T15:25:48","date_gmt":"2024-11-30T21:25:48","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/11\/scientists-identify-a-form-of-vitamin-b6-as-a-means-of-engaging-tumor-reactive-immune-cells"},"modified":"2024-11-30T15:25:48","modified_gmt":"2024-11-30T21:25:48","slug":"scientists-identify-a-form-of-vitamin-b6-as-a-means-of-engaging-tumor-reactive-immune-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/11\/scientists-identify-a-form-of-vitamin-b6-as-a-means-of-engaging-tumor-reactive-immune-cells","title":{"rendered":"Scientists identify a form of vitamin B6 as a means of engaging tumor-reactive immune cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-identify-a-form-of-vitamin-b6-as-a-means-of-engaging-tumor-reactive-immune-cells.jpg\"><\/a><\/p>\n<p>Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1 allows sensing of certain small molecule metabolites derived from cellular and microbial sources; however, the breadth of metabolite sensing is unclear.<\/p>\n<p>Published in <i>PNAS<\/i>, researchers at the Monash University Biomedicine Discovery Institute have <a href=\"https:\/\/pnas.org\/doi\/10.1073\/pnas.2414792121\" target=\"_blank\">identified<\/a> a form of vitamin B6 bound to MR1 as a means of engaging tumor-reactive <a href=\"https:\/\/medicalxpress.com\/tags\/immune+cells\/\" rel=\"tag\" class=\"\">immune cells<\/a>. The work involved an international collaborative team co-led by researchers from the University of Melbourne.<\/p>\n<p>According to Dr. Illing, \u201cOur findings suggest that vitamin B6 molecules displayed by MR1 represent a means for the <a href=\"https:\/\/medicalxpress.com\/tags\/immune+system\/\" rel=\"tag\" class=\"\">immune system<\/a> to detect altered cellular metabolism\/metabolite levels, that may distinguish <a href=\"https:\/\/medicalxpress.com\/tags\/cancer+cells\/\" rel=\"tag\" class=\"\">cancer cells<\/a>,\u201d she said.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1 allows sensing of certain small molecule metabolites derived from cellular and microbial sources; however, the breadth of metabolite sensing is unclear. Published in PNAS, researchers at the Monash University [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-200499","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/200499","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=200499"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/200499\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=200499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=200499"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=200499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}