{"id":200050,"date":"2024-11-23T21:42:21","date_gmt":"2024-11-24T03:42:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/11\/developing-an-organic-transmembrane-device-to-host-and-monitor-3d-cell-cultures"},"modified":"2024-11-23T21:42:21","modified_gmt":"2024-11-24T03:42:21","slug":"developing-an-organic-transmembrane-device-to-host-and-monitor-3d-cell-cultures","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/11\/developing-an-organic-transmembrane-device-to-host-and-monitor-3d-cell-cultures","title":{"rendered":"Developing an organic transmembrane device to host and monitor 3D cell cultures"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/developing-an-organic-transmembrane-device-to-host-and-monitor-3d-cell-cultures2.jpg\"><\/a><\/p>\n<p>Researchers have used 3D cell culture models in the past decade to translate molecular targets during drug discovery processes to thereby transition from an existing predominantly 2D culture environment. In a new report now published in <i>Science Advances<\/i>, Charalampos Pitsalidis and a research team in physics and chemical engineering at the University of Science and Technology in Abu Dhabi, UAE and the University of Cambridge describe a multi-well plate bioelectronic platform named the e-transmembrane to support and monitor complex 3D cell architectures.<\/p>\n<p>The team microengineered the scaffolds using <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.8b00029\" target=\"_blank\">poly(3,4-ethylenedioxythiophene polystyrene sulfonate<\/a> to function as separating membranes to isolate cell cultures and achieve real-time in situ recordings of cell growth and function. The <a href=\"https:\/\/phys.org\/tags\/high+surface+area\/\" rel=\"tag\" class=\"\">high surface area<\/a> to volume ratio allowed them to generate deep stratified tissues in a porous architecture. The platform is applicable as a universal resource for biologists to conduct next-generation high-throughput drug screening assays.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have used 3D cell culture models in the past decade to translate molecular targets during drug discovery processes to thereby transition from an existing predominantly 2D culture environment. In a new report now published in Science Advances, Charalampos Pitsalidis and a research team in physics and chemical engineering at the University of Science and [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,38],"tags":[],"class_list":["post-200050","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-engineering"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/200050","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=200050"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/200050\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=200050"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=200050"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=200050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}