{"id":199659,"date":"2024-11-17T19:23:01","date_gmt":"2024-11-18T01:23:01","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/11\/researchers-uncover-new-role-of-mutant-proteins-in-some-of-the-deadliest-cancers"},"modified":"2024-11-17T19:23:01","modified_gmt":"2024-11-18T01:23:01","slug":"researchers-uncover-new-role-of-mutant-proteins-in-some-of-the-deadliest-cancers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/11\/researchers-uncover-new-role-of-mutant-proteins-in-some-of-the-deadliest-cancers","title":{"rendered":"Researchers uncover new role of mutant proteins in some of the deadliest cancers"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-uncover-new-role-of-mutant-proteins-in-some-of-the-deadliest-cancers2.jpg\"><\/a><\/p>\n<p>Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a new way in which RAS genes, which are commonly mutated in cancer, may drive tumor growth beyond their well-known role in signaling at the cell surface.<\/p>\n<p>Mutant RAS, they found, helps to kick off a series of events involving the transport of specific nuclear proteins that lead to uncontrolled <a href=\"https:\/\/medicalxpress.com\/tags\/tumor+growth\/\" rel=\"tag\" class=\"\">tumor growth<\/a>, according to a study <a href=\"https:\/\/www.nature.com\/articles\/s43018-024-00847-5\" target=\"_blank\">published<\/a> November 11, 2024, in Nature Cancer.<\/p>\n<p>RAS <a href=\"https:\/\/medicalxpress.com\/tags\/genes\/\" rel=\"tag\" class=\"\">genes<\/a> are the second most frequently mutated genes in cancer, and mutant RAS proteins are key drivers of some of the deadliest cancers, including nearly all <a href=\"https:\/\/medicalxpress.com\/tags\/pancreatic+cancers\/\" rel=\"tag\" class=\"\">pancreatic cancers<\/a>, half of colorectal cancers, and one-third of lung cancers.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a new way in which RAS genes, which are commonly mutated in cancer, may drive tumor growth beyond their well-known role in signaling at the cell surface. Mutant RAS, they found, helps to kick off a series of events involving the transport [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-199659","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/199659","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=199659"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/199659\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=199659"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=199659"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=199659"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}