{"id":198343,"date":"2024-10-26T12:22:27","date_gmt":"2024-10-26T17:22:27","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/10\/fathers-gut-bacteria-impact-offspring-health"},"modified":"2024-10-26T12:22:27","modified_gmt":"2024-10-26T17:22:27","slug":"fathers-gut-bacteria-impact-offspring-health","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/10\/fathers-gut-bacteria-impact-offspring-health","title":{"rendered":"Fathers\u2019 Gut Bacteria Impact Offspring Health"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/fathers-gut-bacteria-impact-offspring-health2.jpg\"><\/a><\/p>\n<p>ABOVE: The placenta\u2019s labyrinth zone (red), responsible for nutrient exchange between mother and fetus, is reduced in fetuses with dysbiotic fathers (lower panel) compared to healthy fathers (upper panel). Ayele Argaw-Denboba.<\/p>\n<p>The microbiome has a profound impact on host health that extends to the host\u2019s young ones. Studies in mice have shown that maternal gut bacteria play a role in <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(16)30730-9\" target=\"_blank\">offspring behavior<\/a> and <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adk1887\" target=\"_blank\">placental growth<\/a> during pregnancy.<sup>1,2 <\/sup> Yet, the effects of the paternal microbiome on the health of their progeny remained relatively unexplored.<\/p>\n<p>In a new study, scientists found that altering the <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-07336-w\" target=\"_blank\">gut microbiome of male mice<\/a> negatively affected the health and lifespan of their offspring through epigenetic changes in the sperm.<sup>3<\/sup> The results, published in <em>Nature<\/em>, offer insights into a gut-germline axis that mediates the effects of the microbiome on health and disease across generations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ABOVE: The placenta\u2019s labyrinth zone (red), responsible for nutrient exchange between mother and fetus, is reduced in fetuses with dysbiotic fathers (lower panel) compared to healthy fathers (upper panel). Ayele Argaw-Denboba. The microbiome has a profound impact on host health that extends to the host\u2019s young ones. Studies in mice have shown that maternal gut [\u2026]<\/p>\n","protected":false},"author":692,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,1495],"tags":[],"class_list":["post-198343","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/198343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/692"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=198343"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/198343\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=198343"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=198343"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=198343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}