{"id":197883,"date":"2024-10-17T23:33:25","date_gmt":"2024-10-18T04:33:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/10\/frontiers-to-date-the-most-studied-drug-in-anti-aging-research-is-the-mtor-inhibitor-rapamycin"},"modified":"2024-10-17T23:33:25","modified_gmt":"2024-10-18T04:33:25","slug":"frontiers-to-date-the-most-studied-drug-in-anti-aging-research-is-the-mtor-inhibitor-rapamycin","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/10\/frontiers-to-date-the-most-studied-drug-in-anti-aging-research-is-the-mtor-inhibitor-rapamycin","title":{"rendered":"Frontiers: To date, the most studied drug in anti-aging research is the mTOR inhibitor \u2013 rapamycin"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/frontiers24.jpg\"><\/a><\/p>\n<p>Despite its almost perfect anti-aging profile, rapamycin exerts one significant limitation \u2013 inappropriate physicochemical properties. Therefore, we have decided to utilize virtual high-throughput screening and fragment-based design in search of novel mTOR inhibiting scaffolds with suitable physicochemical parameters. Seven lead compounds were selected from the list of obtained hits that were commercially available (<b>4, 5,<\/b> and <b>7<\/b>) or their synthesis was feasible (<b>1, 2, 3,<\/b> and <b>6<\/b>) and evaluated <i>in vitro<\/i> and subsequently <i>in vivo<\/i>. Of all these substances, only compound <b>3<\/b> demonstrated a significant cytotoxic, senolytic, and senomorphic effect on normal and cancerous cells. Further, it has been confirmed that compound <b>3<\/b> is a direct mTORC1 inhibitor. Last but not least, compound <b>3<\/b> was found to exhibit anti-SASP activity concurrently being relatively safe within the test of <i>in vivo<\/i> tolerability. All these outstanding results highlight compound <b>3<\/b> as a scaffold worthy of further investigation.<\/p>\n<p>GRAPHICAL ABSTRACT<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Despite its almost perfect anti-aging profile, rapamycin exerts one significant limitation \u2013 inappropriate physicochemical properties. Therefore, we have decided to utilize virtual high-throughput screening and fragment-based design in search of novel mTOR inhibiting scaffolds with suitable physicochemical parameters. Seven lead compounds were selected from the list of obtained hits that were commercially available (4, 5, [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,269],"tags":[],"class_list":["post-197883","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/197883","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=197883"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/197883\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=197883"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=197883"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=197883"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}