{"id":197650,"date":"2024-10-14T13:23:54","date_gmt":"2024-10-14T18:23:54","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/10\/fever-drives-enhanced-activity-mitochondrial-damage-in-immune-cells"},"modified":"2024-10-14T13:23:54","modified_gmt":"2024-10-14T18:23:54","slug":"fever-drives-enhanced-activity-mitochondrial-damage-in-immune-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/10\/fever-drives-enhanced-activity-mitochondrial-damage-in-immune-cells","title":{"rendered":"Fever Drives Enhanced Activity, Mitochondrial Damage in Immune Cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/fever-drives-enhanced-activity-mitochondrial-damage-in-immune-cells.jpg\"><\/a><\/p>\n<p>Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also \u2014 in a particular subset of T cells \u2014 cause mitochondrial stress, DNA damage and cell death, Vanderbilt University Medical Center researchers have discovered.<\/p>\n<p>The findings, published Sept. 20 in the journal Science Immunology, offer a mechanistic understanding for how cells respond to heat and could explain how chronic inflammation contributes to the development of cancer.<\/p>\n<p>The impact of fever temperatures on cells is a relatively understudied area, said Jeff Rathmell, PhD, Cornelius Vanderbilt Professor of Immunobiology and corresponding author of the new study. Most of the existing temperature-related research relates to agriculture and how extreme temperatures impact crops and livestock, he noted. It\u2019s challenging to change the temperature of animal models without causing stress, and cells in the laboratory are generally cultured in incubators that are set at human body temperature: 37 degrees Celsius (98.6 degrees Fahrenheit).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also \u2014 in a particular subset of T cells \u2014 cause mitochondrial stress, DNA damage and cell death, Vanderbilt University Medical Center researchers have discovered. The findings, published Sept. 20 in the journal Science Immunology, offer a mechanistic understanding for how cells respond [\u2026]<\/p>\n","protected":false},"author":707,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1506],"tags":[],"class_list":["post-197650","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-food"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/197650","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/707"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=197650"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/197650\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=197650"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=197650"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=197650"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}