{"id":197505,"date":"2024-10-12T09:43:02","date_gmt":"2024-10-12T14:43:02","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/10\/phenomenal-tool-sequences-dna-and-tracks-proteins-without-cracking-cells-open"},"modified":"2024-10-12T09:43:02","modified_gmt":"2024-10-12T14:43:02","slug":"phenomenal-tool-sequences-dna-and-tracks-proteins-without-cracking-cells-open","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/10\/phenomenal-tool-sequences-dna-and-tracks-proteins-without-cracking-cells-open","title":{"rendered":"\u2018Phenomenal\u2019 tool sequences DNA and tracks proteins \u2014 without cracking cells open"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/phenomenal-tool-sequences-dna-and-tracks-proteins-without-cracking-cells-open2.jpg\"><\/a><\/p>\n<p>Researchers are queuing up to try a powerful microscopy technique that can simultaneously sequence an individual cell\u2019s DNA and pinpoint the location of its proteins with high resolution \u2014 all without having to crack the cell open and extract its contents. Imaging DNA and proteins inside intact cells provides crucial information about how these molecules work together.<\/p>\n<p>The method\u2019s developers have already used it to study how ageing might alter the way that <a href=\"https:\/\/www.nature.com\/articles\/d41586-023-00334-4\">proteins in the nucleus<\/a> interact with chromosomes. <a href=\"https:\/\/www.nature.com\/articles\/d41586-023-01040-x\">As the body ages<\/a>, they found, changes in these nuclear proteins could suppress gene activity.<\/p>\n<p>\u201cThis paper is really extraordinary,\u201d says Ankur Sharma, a cancer biologist at the Garvan Institute of Medical Research in Sydney, Australia, who was not involved in the study but is keen to use the approach to study <a href=\"https:\/\/www.nature.com\/articles\/d41586-021-01029-4\">cancer cells<\/a> and described it as \u201cphenomenal\u201d on the social-media platform, X.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers are queuing up to try a powerful microscopy technique that can simultaneously sequence an individual cell\u2019s DNA and pinpoint the location of its proteins with high resolution \u2014 all without having to crack the cell open and extract its contents. Imaging DNA and proteins inside intact cells provides crucial information about how these molecules [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-197505","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/197505","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=197505"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/197505\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=197505"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=197505"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=197505"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}