{"id":196918,"date":"2024-10-02T11:26:05","date_gmt":"2024-10-02T16:26:05","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/10\/scientists-learn-how-to-drug-wily-class-of-disease-causing-enzymes"},"modified":"2024-10-02T11:26:05","modified_gmt":"2024-10-02T16:26:05","slug":"scientists-learn-how-to-drug-wily-class-of-disease-causing-enzymes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/10\/scientists-learn-how-to-drug-wily-class-of-disease-causing-enzymes","title":{"rendered":"Scientists Learn how to Drug Wily Class of Disease-Causing Enzymes"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/scientists-learn-how-to-drug-wily-class-of-disease-causing-enzymes2.jpg\"><\/a><\/p>\n<p>Drugs for the K-Ras oncogene inspire an approach for targeting the GTPases, a family of enzymes whose dysfunction can lead to Parkinson\u2019s and many other diseases.<\/p>\n<p>UCSF scientists have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases from Parkinson\u2019s to cancer and have long been thought to be \u201cundruggable.\u201d<\/p>\n<p>Because of their slippery exteriors, the GTPases have remained largely out of reach of modern drug discovery, with the exception of the notorious cancer-causing GTPase called K-Ras.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Drugs for the K-Ras oncogene inspire an approach for targeting the GTPases, a family of enzymes whose dysfunction can lead to Parkinson\u2019s and many other diseases. UCSF scientists have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases from Parkinson\u2019s to cancer and have long [\u2026]<\/p>\n","protected":false},"author":707,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-196918","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/196918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/707"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=196918"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/196918\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=196918"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=196918"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=196918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}