{"id":196335,"date":"2024-09-18T07:25:06","date_gmt":"2024-09-18T12:25:06","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/09\/why-some-organs-age-faster-than-others-scientists-discover-hidden-mutations-in-non-coding-dna"},"modified":"2024-09-18T07:25:06","modified_gmt":"2024-09-18T12:25:06","slug":"why-some-organs-age-faster-than-others-scientists-discover-hidden-mutations-in-non-coding-dna","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/09\/why-some-organs-age-faster-than-others-scientists-discover-hidden-mutations-in-non-coding-dna","title":{"rendered":"Why some organs age faster than others: Scientists discover hidden mutations in non-coding DNA"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/why-some-organs-age-faster-than-others-scientists-discover-hidden-mutations-in-non-coding-dna2.jpg\"><\/a><\/p>\n<p>The accumulation of mutations in DNA is often mentioned as an explanation for the aging process, but it remains just one hypothesis among many. A team from the University of Geneva (UNIGE), in collaboration with the Inselspital, University Hospital of Bern and the University of Bern (UNIBE), has identified a mechanism that explains why certain organs, such as the liver, age more rapidly than others.<\/p>\n<p>The mechanism reveals that damages to non-coding DNA, which are often hidden, accumulate more in slowly proliferating tissues, such as those of the liver or kidneys. Unlike in organs that regenerate frequently, these damages remain undetected for a long time and prevent <a href=\"https:\/\/medicalxpress.com\/tags\/cell+division\/\" rel=\"tag\" class=\"\">cell division<\/a>. These results, <a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867424009632\" target=\"_blank\">published<\/a> in the journal <i>Cell<\/i>, open new avenues for understanding cellular aging and potentially slowing it down.<\/p>\n<p>Our organs and tissues do not all age at the same rate. Aging, marked by an increase in <a href=\"https:\/\/medicalxpress.com\/tags\/senescent+cells\/\" rel=\"tag\" class=\"\">senescent cells <\/a>\u2014cells that are unable to divide and have lost their functions\u2014affects the liver or kidneys more rapidly than the skin or intestine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The accumulation of mutations in DNA is often mentioned as an explanation for the aging process, but it remains just one hypothesis among many. A team from the University of Geneva (UNIGE), in collaboration with the Inselspital, University Hospital of Bern and the University of Bern (UNIBE), has identified a mechanism that explains why certain [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-196335","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/196335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=196335"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/196335\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=196335"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=196335"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=196335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}