{"id":195072,"date":"2024-08-23T13:22:56","date_gmt":"2024-08-23T18:22:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/08\/miller-school-scientists-reveal-mechanisms-behind-gene-expression-in-mitochondria"},"modified":"2024-08-23T13:22:56","modified_gmt":"2024-08-23T18:22:56","slug":"miller-school-scientists-reveal-mechanisms-behind-gene-expression-in-mitochondria","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/08\/miller-school-scientists-reveal-mechanisms-behind-gene-expression-in-mitochondria","title":{"rendered":"Miller School Scientists Reveal Mechanisms Behind Gene Expression in Mitochondria"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/miller-school-scientists-reveal-mechanisms-behind-gene-expression-in-mitochondria2.jpg\"><\/a><\/p>\n<p>A molecular biology research team at the University of Miami Miller School of Medicine has become the first to map out how mitochondrial messenger RNA folds in human cells.<\/p>\n<p>The research advances knowledge about the expression of genes in the mitochondria and paves the way for identification of therapeutic targets for mitochondrial neurodegenerative diseases.<\/p>\n<p>\u201cDysfunctional mitochondria can cause devastating diseases, frequently with childhood-onset, known as mitochondrial encephalomyopathies. Despite advances in identifying genes responsible for these disorders, their pathophysiological mechanisms have been poorly understood,\u201d said <a href=\"https:\/\/med.miami.edu\/faculty\/antonio-barrientos-phd\">Antoni Barrientos, Ph.D.,<\/a> professor of <a href=\"https:\/\/med.miami.edu\/departments\/neurology\">neurology<\/a> and <a href=\"https:\/\/med.miami.edu\/departments\/biochemistry-and-molecular-biology\">biochemistry and molecular biology<\/a> at the Miller School. \u201cThis was partly due to a lack of a full understanding of mitochondrial gene expression. Specifically, nothing was known about how mitochondrial messenger RNA folds and how that could influence its stability and translation in health and disease.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A molecular biology research team at the University of Miami Miller School of Medicine has become the first to map out how mitochondrial messenger RNA folds in human cells. The research advances knowledge about the expression of genes in the mitochondria and paves the way for identification of therapeutic targets for mitochondrial neurodegenerative diseases. \u201cDysfunctional [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,1495,47],"tags":[],"class_list":["post-195072","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-health","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/195072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=195072"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/195072\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=195072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=195072"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=195072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}