{"id":194149,"date":"2024-08-06T16:25:23","date_gmt":"2024-08-06T21:25:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/08\/research-team-reveals-how-trem2-genetic-mutation-affects-late-onset-alzheimers"},"modified":"2024-08-06T16:25:23","modified_gmt":"2024-08-06T21:25:23","slug":"research-team-reveals-how-trem2-genetic-mutation-affects-late-onset-alzheimers","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/08\/research-team-reveals-how-trem2-genetic-mutation-affects-late-onset-alzheimers","title":{"rendered":"Research team reveals how TREM2 genetic mutation affects late-onset Alzheimer\u2019s"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/research-team-reveals-how-trem2-genetic-mutation-affects-late-onset-alzheimers3.jpg\"><\/a><\/p>\n<p>Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer\u2019s disease. Leveraging single-cell Merfish spatial transcriptomics technology, the team was able to profile the effects of the mutation across multiple cortical and subcortical brain regions, offering first-of-their-kind insights at the single-cell level.<\/p>\n<p>The study, <a href=\"https:\/\/www.nature.com\/articles\/s41380-024-02651-0\" target=\"_blank\">published<\/a> in <i>Molecular Psychiatry<\/i>, compared the brains of normal mice and special mouse models that undergo changes like those in humans with Alzheimer\u2019s.<\/p>\n<p>Findings revealed that the TREM2 mutation led to divergent patterns of beta-amyloid plaque accumulation in various parts of the brain involved in higher-level functions such as memory, reasoning and speech. It also affected certain <a href=\"https:\/\/medicalxpress.com\/tags\/cell+types\/\" rel=\"tag\" class=\"\">cell types<\/a> and their gene expression near the plaques.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer\u2019s disease. Leveraging single-cell Merfish spatial transcriptomics technology, the team was able to profile the effects of the mutation across multiple cortical and subcortical [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-194149","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/194149","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=194149"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/194149\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=194149"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=194149"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=194149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}