{"id":194020,"date":"2024-08-04T10:22:36","date_gmt":"2024-08-04T15:22:36","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/08\/anti-aging-antibodies"},"modified":"2024-08-04T10:22:36","modified_gmt":"2024-08-04T15:22:36","slug":"anti-aging-antibodies","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/08\/anti-aging-antibodies","title":{"rendered":"Anti-Aging Antibodies?"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/tR92lBve_gY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>There\u2019s only one alliterative phrase i like more than \u2018the sheekey science show\u2019, and that\u2019s \u2018anti-aging antibodies\u2019. now, as it happens, one thing i spent a lot of time working on this year is antibodies. Antibody, make me feel this way. now while i cannot tell you yet what i was\/am doing, i can tell you about two recent science stories that exploit antibodies to extend mouse lifespan. Firstly, i will bring your attention to this paper \u2014 immunotherapy targeting isoDGR-protein damage extends lifespan and then we\u2019ll look at this paper that came out last month \u2014 Inhibition of IL-11 signalling extends mammalian healthspan.<\/p>\n<p>Find me on Twitter \u2014 \/ eleanorsheekey.<\/p>\n<p>Support the channel.<br \/> through PayPal \u2014 <a href=\"https:\/\/paypal.me\/sheekeyscience?coun\">https:\/\/paypal.me\/sheekeyscience?coun<\/a>\u2026<br \/> through Patreon \u2014 \/ thesheekeyscienceshow.<\/p>\n<p>TIMESTAMPS:<br \/> Intro \u2014 00:00<br \/> Antibodies \u2014 00:45<br \/> Inhibiting protein damage \u2014 02:15<br \/> Inhibiting IL-11 \u2014 05:20<\/p>\n<p>REFERENCES<br \/> Immunotherapy targeting isoDGR\u2010protein damage extends lifespan in a mouse model of protein deamidation \u2014 <a href=\"https:\/\/doi.org\/10.15252\/emmm.202318526\">https:\/\/doi.org\/10.15252\/emmm.202318526<\/a><br \/> Widjaja, A.A., Lim, WW., Viswanathan, S. et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632157\u2013165 (2024). <a href=\"https:\/\/doi.org\/10.1038\/s41586-024-07\">https:\/\/doi.org\/10.1038\/s41586-024-07<\/a>\u2026<\/p>\n<p>Please note that The Sheekey Science Show is distinct from Eleanor Sheekey\u2019s teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2024\/08\/anti-aging-antibodies\">Continue reading \u201cAnti-Aging Antibodies?\u201d | &gt;<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>There\u2019s only one alliterative phrase i like more than \u2018the sheekey science show\u2019, and that\u2019s \u2018anti-aging antibodies\u2019. now, as it happens, one thing i spent a lot of time working on this year is antibodies. Antibody, make me feel this way. now while i cannot tell you yet what i was\/am doing, i can tell [\u2026]<\/p>\n","protected":false},"author":388,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,32,269],"tags":[],"class_list":["post-194020","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-education","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/194020","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/388"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=194020"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/194020\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=194020"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=194020"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=194020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}