{"id":193730,"date":"2024-07-29T23:17:26","date_gmt":"2024-07-30T04:17:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/07\/drugs-that-kill-zombie-cells-may-benefit-some-older-women-but-not-all"},"modified":"2024-07-29T23:17:26","modified_gmt":"2024-07-30T04:17:26","slug":"drugs-that-kill-zombie-cells-may-benefit-some-older-women-but-not-all","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/07\/drugs-that-kill-zombie-cells-may-benefit-some-older-women-but-not-all","title":{"rendered":"Drugs that Kill \u2018Zombie\u2019 Cells may Benefit some Older Women, but not all"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/drugs-that-kill-zombie-cells-may-benefit-some-older-women-but-not-all2.jpg\"><\/a><\/p>\n<p>Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a \u201cone-size-fits-all\u201d remedy, Mayo Clinic researchers have found. Specifically, these drugs may only benefit people with a high number of senescent cells, according to findings publishing July 2 in Nature Medicine.<\/p>\n<p>Senescent cells are malfunctioning cells in the body that lapse into a state of dormancy. These cells, also known as \u201czombie cells,\u201d can\u2019t divide but can drive chronic inflammation and tissue dysfunction linked to aging and chronic diseases. Senolytic drugs clear tissues of senescent cells.<\/p>\n<p>In the 20-week, phase 2 randomized controlled trial, 60 healthy women past menopause intermittently received a senolytic combination composed of FDA-approved dasatinib and quercetin, a natural product found in some foods. It is the first randomized controlled trial of intermittent senolytic treatment in healthy aging women, and the investigators used bone metabolism as a marker for efficacy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Drugs that selectively kill senescent cells may benefit otherwise healthy older women but are not a \u201cone-size-fits-all\u201d remedy, Mayo Clinic researchers have found. Specifically, these drugs may only benefit people with a high number of senescent cells, according to findings publishing July 2 in Nature Medicine. Senescent cells are malfunctioning cells in the body that [\u2026]<\/p>\n","protected":false},"author":707,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1506,269],"tags":[],"class_list":["post-193730","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-food","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/193730","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/707"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=193730"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/193730\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=193730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=193730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=193730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}