{"id":192394,"date":"2024-07-05T20:03:45","date_gmt":"2024-07-06T01:03:45","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/07\/re-engineering-cancerous-tumors-to-self-destruct-and-kill-drug-resistant-cells"},"modified":"2024-07-05T20:03:45","modified_gmt":"2024-07-06T01:03:45","slug":"re-engineering-cancerous-tumors-to-self-destruct-and-kill-drug-resistant-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/07\/re-engineering-cancerous-tumors-to-self-destruct-and-kill-drug-resistant-cells","title":{"rendered":"Re-engineering cancerous tumors to self-destruct and kill drug-resistant cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/re-engineering-cancerous-tumors-to-self-destruct-and-kill-drug-resistant-cells2.jpg\"><\/a><\/p>\n<p>Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind. But a team led by Penn State researchers has found a way to reprogram disease evolution and design tumors that are easier to treat.<\/p>\n<p>They created a modular genetic circuit that turns cancer cells into a \u201cTrojan horse,\u201d causing them to self-destruct and kill nearby drug-resistant cancer cells. Tested in human cell lines and in mice as proof of concept, the circuit outsmarted a wide range of <a href=\"https:\/\/medicalxpress.com\/tags\/resistance\/\" rel=\"tag\" class=\"\">resistance<\/a>.<\/p>\n<p>The findings were published today, July 4, in the journal <a href=\"https:\/\/www.nature.com\/articles\/s41587-024-02271-7\" target=\"_blank\"><i>Nature Biotechnology<\/i><\/a>. The researchers also filed a provisional application to patent the technology described in the paper.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind. But a team led by Penn State researchers has found a way to reprogram disease evolution and design tumors that are easier [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,385,412],"tags":[],"class_list":["post-192394","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-evolution","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/192394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=192394"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/192394\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=192394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=192394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=192394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}