{"id":191493,"date":"2024-06-20T00:27:49","date_gmt":"2024-06-20T05:27:49","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/06\/targeted-covalent-inhibition-of-telomerase"},"modified":"2024-06-20T00:27:49","modified_gmt":"2024-06-20T05:27:49","slug":"targeted-covalent-inhibition-of-telomerase","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/06\/targeted-covalent-inhibition-of-telomerase","title":{"rendered":"Targeted Covalent Inhibition of Telomerase"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/targeted-covalent-inhibition-of-telomerase3.jpg\"><\/a><\/p>\n<p>I think this could lead to immortality basically allowing for limited growth of dna structures but still offering unlimited lifespan. In short this also prevents cancer aswell.<\/p>\n<hr>\n<p>Telomerase is a ribonuceloprotein complex responsible for maintaining telomeres and protecting chromosomal integrity. The human telomerase reverse transcriptase (hTERT) is expressed in \u223c90% of cancer cells where it confers the capacity for limitless proliferation. Along with its established role in telomere lengthening, telomerase also serves noncanonical extra-telomeric roles in oncogenic signaling, resistance to apoptosis, and enhanced DNA damage response. We report a new class of natural-product-inspired covalent inhibitors of telomerase that target the catalytic active site.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I think this could lead to immortality basically allowing for limited growth of dna structures but still offering unlimited lifespan. In short this also prevents cancer aswell. Telomerase is a ribonuceloprotein complex responsible for maintaining telomeres and protecting chromosomal integrity. The human telomerase reverse transcriptase (hTERT) is expressed in \u223c90% of cancer cells where it [\u2026]<\/p>\n","protected":false},"author":513,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-191493","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/191493","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/513"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=191493"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/191493\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=191493"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=191493"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=191493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}