{"id":189868,"date":"2024-05-22T09:38:39","date_gmt":"2024-05-22T14:38:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/05\/groundbreaking-advance-in-brain-science-creating-human-blood-brain-barrier-assembloids"},"modified":"2024-05-22T09:38:39","modified_gmt":"2024-05-22T14:38:39","slug":"groundbreaking-advance-in-brain-science-creating-human-blood-brain-barrier-assembloids","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/05\/groundbreaking-advance-in-brain-science-creating-human-blood-brain-barrier-assembloids","title":{"rendered":"Groundbreaking Advance in Brain Science: Creating Human Blood-Brain Barrier \u2018Assembloids\u2019"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/groundbreaking-advance-in-brain-science-creating-human-blood-brain-barrier-assembloids3.jpg\"><\/a><\/p>\n<p>In a pioneering achievement, a research team led by experts at Cincinnati Children\u2019s have developed the world\u2019s first human mini-brain that incorporates a fully functional blood-brain barrier (BBB).<\/p>\n<p>This major advance, <a href=\"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(24)00146-2#%20\">published May 15, 2024, in<em> Cell Stem Cell<\/em><\/a>, promises to accelerate the understanding and improved treatment of a wide range of brain disorders, including stroke, cerebral vascular disorders, brain cancer, Alzheimer\u2019s disease, Huntington disease, Parkinson\u2019s disease, and other neurodegenerative conditions.<\/p>\n<p>\u201cLack of an authentic human BBB model has been a major hurdle in studying neurological diseases,\u201d says lead corresponding author <a href=\"https:\/\/www.cincinnatichildrens.org\/bio\/g\/ziyuan-guo\">Ziyuan Guo, PhD<\/a>, \u201cOur breakthrough involves the generation of human BBB organoids from human pluripotent stem cells, mimicking human neurovascular development to produce a faithful representation of the barrier in growing, functioning brain tissue. This is an important advance because animal models we currently use in research do not accurately reflect human brain development and BBB functionality.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a pioneering achievement, a research team led by experts at Cincinnati Children\u2019s have developed the world\u2019s first human mini-brain that incorporates a fully functional blood-brain barrier (BBB). This major advance, published May 15, 2024, in Cell Stem Cell, promises to accelerate the understanding and improved treatment of a wide range of brain disorders, including [\u2026]<\/p>\n","protected":false},"author":701,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47,224],"tags":[],"class_list":["post-189868","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience","category-science"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/189868","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/701"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=189868"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/189868\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=189868"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=189868"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=189868"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}