{"id":188215,"date":"2024-04-27T02:27:19","date_gmt":"2024-04-27T07:27:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/04\/breakthrough-rare-gene-mutation-offers-clues-to-preventing-type-1-diabetes"},"modified":"2024-04-27T02:27:19","modified_gmt":"2024-04-27T07:27:19","slug":"breakthrough-rare-gene-mutation-offers-clues-to-preventing-type-1-diabetes","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/04\/breakthrough-rare-gene-mutation-offers-clues-to-preventing-type-1-diabetes","title":{"rendered":"Breakthrough: Rare Gene Mutation Offers Clues to Preventing Type 1 Diabetes"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/breakthrough-rare-gene-mutation-offers-clues-to-preventing-type-1-diabetes2.jpg\"><\/a><\/p>\n<p>A unique genetic mutation in two siblings \u2013 that has never been seen in anyone else \u2013 has been discovered by UK researchers at the University of Exeter, pointing the way towards new treatment options for <a href=\"https:\/\/www.sciencealert.com\/new-biomaterial-for-type-1-diabetes-transplant-shows-exciting-results-in-small-preclinical-trial\">type 1 diabetes<\/a>.<\/p>\n<p>The mutation is in the gene for a protein called <a href=\"https:\/\/en.wikipedia.org\/wiki\/PD-L1\">programmed death-ligand 1<\/a> (PD-L1), and a new study explains how it may be responsible for the autoimmune form of <a href=\"https:\/\/www.sciencealert.com\/diabetes\" class=\"\" rel=\"nofollow\" target=\"_self\">diabetes<\/a> that the children developed at a very young age.<\/p>\n<p>\u201cWe searched the globe, looking at all the large-scale datasets that we know of, and we haven\u2019t been able to find another family,\u201d <a href=\"https:\/\/news.exeter.ac.uk\/faculty-of-health-and-life-sciences\/siblings-with-unique-genetic-change-help-scientists-progress-drug-search-for-type-1-diabetes\/\">says<\/a> molecular geneticist Matthew Johnson, from the University of Exeter in the UK.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A unique genetic mutation in two siblings \u2013 that has never been seen in anyone else \u2013 has been discovered by UK researchers at the University of Exeter, pointing the way towards new treatment options for type 1 diabetes. The mutation is in the gene for a protein called programmed death-ligand 1 (PD-L1), and a [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-188215","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/188215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=188215"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/188215\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=188215"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=188215"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=188215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}