{"id":188036,"date":"2024-04-24T16:25:47","date_gmt":"2024-04-24T21:25:47","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/04\/supercomputer-simulation-reveals-new-mechanism-for-membrane-fusion"},"modified":"2024-04-24T16:25:47","modified_gmt":"2024-04-24T21:25:47","slug":"supercomputer-simulation-reveals-new-mechanism-for-membrane-fusion","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/04\/supercomputer-simulation-reveals-new-mechanism-for-membrane-fusion","title":{"rendered":"Supercomputer simulation reveals new mechanism for membrane fusion"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/supercomputer-simulation-reveals-new-mechanism-for-membrane-fusion2.jpg\"><\/a><\/p>\n<p>An intricate simulation performed by UT Southwestern Medical Center researchers using one of the world\u2019s most powerful supercomputers sheds new light on how proteins called SNAREs cause biological membranes to fuse.<\/p>\n<p>Their findings, <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2321447121\" target=\"_blank\">reported<\/a> in the <i>Proceedings of the National Academy of Sciences<\/i>, suggest a new mechanism for this ubiquitous process and could eventually lead to new treatments for conditions in which <a href=\"https:\/\/phys.org\/tags\/membrane+fusion\/\" rel=\"tag\" class=\"\">membrane fusion<\/a> is thought to go awry.<\/p>\n<p>\u201cBiology textbooks say that SNAREs bring membranes together to cause fusion, and many people were happy with that explanation. But not me, because membranes brought into contact normally do not fuse. Our simulation goes deeper to show how this important process takes place,\u201d said study leader Jose Rizo-Rey (\u201cJosep Rizo\u201d), Ph.D., Professor of Biophysics, Biochemistry, and Pharmacology at UT Southwestern.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An intricate simulation performed by UT Southwestern Medical Center researchers using one of the world\u2019s most powerful supercomputers sheds new light on how proteins called SNAREs cause biological membranes to fuse. Their findings, reported in the Proceedings of the National Academy of Sciences, suggest a new mechanism for this ubiquitous process and could eventually lead [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,44],"tags":[],"class_list":["post-188036","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-supercomputing"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/188036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=188036"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/188036\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=188036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=188036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=188036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}