{"id":186959,"date":"2024-04-07T12:22:50","date_gmt":"2024-04-07T17:22:50","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/04\/de-novo-design-of-ph-responsive-self-assembling-helical-protein-filaments"},"modified":"2024-04-07T12:22:50","modified_gmt":"2024-04-07T17:22:50","slug":"de-novo-design-of-ph-responsive-self-assembling-helical-protein-filaments","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/04\/de-novo-design-of-ph-responsive-self-assembling-helical-protein-filaments","title":{"rendered":"De novo design of pH-responsive self-assembling helical protein filaments"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/de-novo-design-of-ph-responsive-self-assembling-helical-protein-filaments2.jpg\"><\/a><\/p>\n<p>Engineering the tunability of protein assembly in response to pH changes within a narrow range is challenging. Here the authors report the de novo computational design of pH-responsive protein filaments that exhibit rapid, precise, tunable and reversible assembly and disassembly triggered by small pH changes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Engineering the tunability of protein assembly in response to pH changes within a narrow range is challenging. Here the authors report the de novo computational design of pH-responsive protein filaments that exhibit rapid, precise, tunable and reversible assembly and disassembly triggered by small pH changes.<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1523,38],"tags":[],"class_list":["post-186959","post","type-post","status-publish","format-standard","hentry","category-computing","category-engineering"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/186959","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=186959"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/186959\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=186959"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=186959"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=186959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}