{"id":186383,"date":"2024-03-30T06:26:26","date_gmt":"2024-03-30T11:26:26","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/03\/synaptic-transmission-not-a-one-way-street-for-key-brain-synapse-in-the-hippocampus"},"modified":"2024-03-30T06:26:26","modified_gmt":"2024-03-30T11:26:26","slug":"synaptic-transmission-not-a-one-way-street-for-key-brain-synapse-in-the-hippocampus","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/03\/synaptic-transmission-not-a-one-way-street-for-key-brain-synapse-in-the-hippocampus","title":{"rendered":"Synaptic Transmission: Not a One-Way Street for Key Brain Synapse in the Hippocampus"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/synaptic-transmission-not-a-one-way-street-for-key-brain-synapse-in-the-hippocampus2.jpg\"><\/a><\/p>\n<p><strong>Key synapse acts as a \u201csmart teacher,\u201d sending messages against the usual flow of information in the brain.<\/strong><\/p>\n<p>Information flows in a well-defined direction in the brain: Chemical and electrical signals are passed from one neuron to the other across the synapse, from the pre-synaptic to the post-synaptic neuron. Now, Peter Jonas and his group at the Institute of Science and Technology Austria (IST Austria) show that information also travels in the opposite direction at a key synapse in the hippocampus, the brain region responsible for learning and memory.<\/p>\n<p>At the so-called mossy fiber synapse, the post-synaptic CA3 neuron influences how the pre-synaptic neuron, the so-called mossy fiber neuron, fires. \u201cWe have shown, for the first time, that a retrograde information flow is physiologically relevant for pre-synaptic plasticity,\u201d says Yuji Okamoto, a postdoc in the group of Peter Jonas at IST Austria and co-first author of the paper published in <em> Nature Communications<\/em>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Key synapse acts as a \u201csmart teacher,\u201d sending messages against the usual flow of information in the brain. Information flows in a well-defined direction in the brain: Chemical and electrical signals are passed from one neuron to the other across the synapse, from the pre-synaptic to the post-synaptic neuron. Now, Peter Jonas and his group [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19,47],"tags":[],"class_list":["post-186383","post","type-post","status-publish","format-standard","hentry","category-chemistry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/186383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=186383"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/186383\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=186383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=186383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=186383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}