{"id":186313,"date":"2024-03-29T16:24:10","date_gmt":"2024-03-29T21:24:10","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/03\/neuropeptide-lacking-in-diabetics-promotes-wound-healing"},"modified":"2024-03-29T16:24:10","modified_gmt":"2024-03-29T21:24:10","slug":"neuropeptide-lacking-in-diabetics-promotes-wound-healing","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/03\/neuropeptide-lacking-in-diabetics-promotes-wound-healing","title":{"rendered":"Neuropeptide Lacking in Diabetics Promotes Wound Healing"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/neuropeptide-lacking-in-diabetics-promotes-wound-healing2.jpg\"><\/a><\/p>\n<p>\u201cIn adults with diabetes alone\u2014where poor blood flow can lead to quickly worsening wounds that are often very slow or impossible to heal\u2014the lifetime risk of developing a diabetic foot ulcer (DFU), the most common diabetes-related wound, is 20\u201335 percent and this number is rising with increased longevity and medical complexity of people with diabetes,\u201d stated lead author, Yen-Zhen Lu, PhD, an investigator at ARMI.<\/p>\n<p>Nociceptors\u2014 neurons that sense pain, tissue damage, and inflammation, among other functions\u2014 respond to wounds by producing a neuropeptide called calcitonin gene-related peptide (CGRP). \u201cNociceptor endings grow into injured skin and muscle tissues and signal to immune cells through the neuropeptide CGRP during the healing process,\u201d the authors wrote. Immune cell response in neutrophils, monocytes, and macrophages are modified to encourage active repair in the region.<\/p>\n<p>Individuals with diseases like diabetes or elderly people have reduced production of CGRP, leading to poor, inefficient, or incomplete wound healing. The new study explores the impact of CGRP alone by introducing it into diabetic mice as well as mice without nociceptors. \u201cDelivery of an engineered version of CGRP accelerated wound healing and promoted muscle regeneration,\u201d the authors wrote. \u201cRemarkably, this neuropeptide acts on immune cells to control them, facilitating tissue healing after injury,\u201d added co-author Mika\u00ebl Martino, PhD, associate professor, ARMI.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cIn adults with diabetes alone\u2014where poor blood flow can lead to quickly worsening wounds that are often very slow or impossible to heal\u2014the lifetime risk of developing a diabetic foot ulcer (DFU), the most common diabetes-related wound, is 20\u201335 percent and this number is rising with increased longevity and medical complexity of people with diabetes,\u201d [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269,47],"tags":[],"class_list":["post-186313","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/186313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=186313"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/186313\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=186313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=186313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=186313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}