{"id":186250,"date":"2024-03-28T16:24:00","date_gmt":"2024-03-28T21:24:00","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/03\/antibody-therapy-rejuvenates-aging-mouse-immune-system-boosting-vaccine-response"},"modified":"2024-03-28T16:24:00","modified_gmt":"2024-03-28T21:24:00","slug":"antibody-therapy-rejuvenates-aging-mouse-immune-system-boosting-vaccine-response","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/03\/antibody-therapy-rejuvenates-aging-mouse-immune-system-boosting-vaccine-response","title":{"rendered":"Antibody Therapy Rejuvenates Aging Mouse Immune System, Boosting Vaccine Response"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/antibody-therapy-rejuvenates-aging-mouse-immune-system-boosting-vaccine-response3.jpg\"><\/a><\/p>\n<p>The results of the team\u2019s research showed that the approach, targeting a subset of hematopoietic stem cells (HSCs) that increase with age, rebalanced blood-cell production and reduced age-related immune decline. The treatment significantly improved the ability of geriatric animals\u2019 immune systems to tackle a new virus, and to respond to vaccination, enabling the animals to fight off a new viral threat months later.<\/p>\n<p>\u201cThis is a real paradigm shift\u2014researchers and clinicians should think in a new way about the immune system and aging,\u201d said Stanford postdoctoral scholar Jason Ross, MD, PhD. \u201cThe idea that it\u2019s possible to tune the entire immune system of millions of cells simply by affecting the function of such a rare population is surprising and exciting.\u201d<\/p>\n<p>Weissman, who is professor of pathology and of developmental biology, and Kim Hasenkrug, PhD, the chief of Rocky Mountain Laboratories\u2019 Retroviral Immunology Section, are senior authors of the team\u2019s published study in <em>Nature<\/em>, titled \u201c<a href=\"https:\/\/doi.org\/10.1038\/s41586-024-07238-x\" target=\"_blank\" rel=\"noopener\">Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity<\/a>.\u201d Ross and Lara Myers, PhD, a research fellow at Rocky Mountain Laboratories, are lead authors of the report, in which the team concluded, \u201cThe clinical development of safe protocols to rebalance HSCs could have broad effects on a number of age-associated issues.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The results of the team\u2019s research showed that the approach, targeting a subset of hematopoietic stem cells (HSCs) that increase with age, rebalanced blood-cell production and reduced age-related immune decline. The treatment significantly improved the ability of geriatric animals\u2019 immune systems to tackle a new virus, and to respond to vaccination, enabling the animals to [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-186250","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/186250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=186250"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/186250\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=186250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=186250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=186250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}