{"id":185890,"date":"2024-03-24T10:24:35","date_gmt":"2024-03-24T15:24:35","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/03\/study-supports-hypothesis-that-mitochondrial-dysregulation-is-a-contributor-to-the-development-of-schizophrenia"},"modified":"2024-03-24T10:24:35","modified_gmt":"2024-03-24T15:24:35","slug":"study-supports-hypothesis-that-mitochondrial-dysregulation-is-a-contributor-to-the-development-of-schizophrenia","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/03\/study-supports-hypothesis-that-mitochondrial-dysregulation-is-a-contributor-to-the-development-of-schizophrenia","title":{"rendered":"Study supports hypothesis that mitochondrial dysregulation is a contributor to the development of schizophrenia"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/study-supports-hypothesis-that-mitochondrial-dysregulation-is-a-contributor-to-the-development-of-schizophrenia2.jpg\"><\/a><\/p>\n<p>Researchers at Rutgers and Emory University are gaining insights into how schizophrenia develops by studying the strongest-known genetic risk factor.<\/p>\n<p>When a small portion of chromosome 3 is missing\u2014known as 3q29 deletion syndrome\u2014it increases the risk for <a href=\"https:\/\/medicalxpress.com\/tags\/schizophrenia\/\" rel=\"tag\" class=\"\">schizophrenia<\/a> by about 40-fold.<\/p>\n<p>Researchers have now analyzed overlapping patterns of altered gene activity in two models of 3q29 deletion syndrome, including mice where the deletion has been engineered in using CRIPSR, and <a href=\"https:\/\/medicalxpress.com\/tags\/human+brain+organoids\/\" rel=\"tag\" class=\"\">human brain organoids<\/a>, or three-dimensional tissue cultures used to study disease. These two systems both exhibit impaired <a href=\"https:\/\/medicalxpress.com\/tags\/mitochondrial+function\/\" rel=\"tag\" class=\"\">mitochondrial function<\/a>. This dysfunction can cause energy shortfalls in the brain and result in psychiatric symptoms and disorders.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Rutgers and Emory University are gaining insights into how schizophrenia develops by studying the strongest-known genetic risk factor. When a small portion of chromosome 3 is missing\u2014known as 3q29 deletion syndrome\u2014it increases the risk for schizophrenia by about 40-fold. Researchers have now analyzed overlapping patterns of altered gene activity in two models of [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412,47],"tags":[],"class_list":["post-185890","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/185890","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=185890"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/185890\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=185890"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=185890"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=185890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}