{"id":185817,"date":"2024-03-23T08:22:49","date_gmt":"2024-03-23T13:22:49","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/03\/researchers-pinpoint-issue-that-could-be-hampering-common-chemotherapy-drug"},"modified":"2024-03-23T08:22:49","modified_gmt":"2024-03-23T13:22:49","slug":"researchers-pinpoint-issue-that-could-be-hampering-common-chemotherapy-drug","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/03\/researchers-pinpoint-issue-that-could-be-hampering-common-chemotherapy-drug","title":{"rendered":"Researchers pinpoint issue that could be hampering common chemotherapy drug"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-pinpoint-issue-that-could-be-hampering-common-chemotherapy-drug2.jpg\"><\/a><\/p>\n<p>Researchers from U of T Medicine pinpoint issue that could be hampering common chemotherapy drug \u27a1\ufe0f<\/p>\n<hr>\n<p>Researchers at the University of Toronto\u2019s Donnelly Centre for Cellular and Biomolecular Research have found two enzymes that work against the chemotherapy drug gemcitabine, preventing it from effectively treating pancreatic cancer.<\/p>\n<p>The enzymes \u2013 APOBEC3C and APOBEC3D \u2013 increase during gemcitabine treatment and promote resistance to DNA replication stress in pancreatic cancer cells.<\/p>\n<p>This, in turn, counteracts the effects of gemcitabine and allows for the growth of cancer cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from U of T Medicine pinpoint issue that could be hampering common chemotherapy drug \u27a1\ufe0f Researchers at the University of Toronto\u2019s Donnelly Centre for Cellular and Biomolecular Research have found two enzymes that work against the chemotherapy drug gemcitabine, preventing it from effectively treating pancreatic cancer. The enzymes \u2013 APOBEC3C and APOBEC3D \u2013 increase [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-185817","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/185817","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=185817"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/185817\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=185817"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=185817"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=185817"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}