{"id":184649,"date":"2024-03-09T02:36:59","date_gmt":"2024-03-09T08:36:59","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/03\/discovery-of-molecular-machine-brings-new-immune-therapies-a-step-closer"},"modified":"2024-03-09T02:36:59","modified_gmt":"2024-03-09T08:36:59","slug":"discovery-of-molecular-machine-brings-new-immune-therapies-a-step-closer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/03\/discovery-of-molecular-machine-brings-new-immune-therapies-a-step-closer","title":{"rendered":"Discovery of \u2018molecular machine\u2019 brings new immune therapies a step closer"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/azs3aNnfI_E?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Guanylate binding proteins (GBP) were discovered by YSM\u2019s John MacMicking, PhD, and colleagues over a decade ago as major organizers of cellular immune response.<\/p>\n<p>In a recent study, MacMicking\u2019s team used advanced cryo-and electron microscope technology to visualize in high resolution the way GBPs\u2026<\/p>\n<hr>\n<p>Yale scientists have discovered a family of immune proteins, which they describe as a \u201cmassive molecular machine,\u201d that could affect the way our bodies fight infection.<\/p>\n<p>Our immune system mobilizes numerous proteins to detect viruses and bacteria \u2014 and to bring them under control. But until recently, limits to research technology have thwarted scientists\u2019 understanding of how to prevent different pathogens from occupying and replicating within specific parts of our cells in the first place.<\/p>\n<p>Harnessing the latest cryo\u2010electron microscopy techniques to look inside human cells, researchers at the Yale Systems Biology Institute have identified a family of large immune proteins that assemble into a massive signaling platform directly on the surface of microbial pathogens.<\/p>\n<div class=\"more-link-wrapper\"> <a class=\"more-link\" href=\"https:\/\/lifeboat.com\/blog\/2024\/03\/discovery-of-molecular-machine-brings-new-immune-therapies-a-step-closer\">Continue reading \u201cDiscovery of \u2018molecular machine\u2019 brings new immune therapies a step closer\u201d | &gt;<\/a><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Guanylate binding proteins (GBP) were discovered by YSM\u2019s John MacMicking, PhD, and colleagues over a decade ago as major organizers of cellular immune response. In a recent study, MacMicking\u2019s team used advanced cryo-and electron microscope technology to visualize in high resolution the way GBPs\u2026 Yale scientists have discovered a family of immune proteins, which they [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4],"tags":[],"class_list":["post-184649","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/184649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=184649"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/184649\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=184649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=184649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=184649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}