{"id":184061,"date":"2024-03-01T11:28:23","date_gmt":"2024-03-01T17:28:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/03\/bad-cholesterol-gene-silenced-without-altering-the-dna-sequence"},"modified":"2024-03-01T11:28:23","modified_gmt":"2024-03-01T17:28:23","slug":"bad-cholesterol-gene-silenced-without-altering-the-dna-sequence","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/03\/bad-cholesterol-gene-silenced-without-altering-the-dna-sequence","title":{"rendered":"\u2018Bad\u2019 cholesterol gene silenced without altering the DNA sequence"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/_aAhcNjmvhc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Because identical twins develop from a single fertilized egg, they have the same genome, the entire set of genetic material found in an organism. So, any differences between them, even in traits with a significant genetic component \u2013 say one develops heart disease and the other doesn\u2019t \u2013 are due to their environments. This is known as epigenetics.<\/p>\n<p>Genes in DNA are \u2018expressed\u2019 when they\u2019re read and transcribed into RNA, which is then translated into proteins. It\u2019s proteins that determine many of a cell\u2019s characteristics and functions. Epigenetic changes can boost or silence the transcription of specific genes, ramping up or inhibiting associated protein production, but they don\u2019t change the genome. These changes, which are reversible, can affect a person for their entire life and mediate a lifelong dialogue between genes and the environment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Because identical twins develop from a single fertilized egg, they have the same genome, the entire set of genetic material found in an organism. So, any differences between them, even in traits with a significant genetic component \u2013 say one develops heart disease and the other doesn\u2019t \u2013 are due to their environments. This is [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-184061","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/184061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=184061"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/184061\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=184061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=184061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=184061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}