{"id":183947,"date":"2024-02-28T17:25:43","date_gmt":"2024-02-28T23:25:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/02\/double-trouble-at-chromosome-ends-new-study-alters-our-understanding-of-telomere-biology"},"modified":"2024-02-28T17:25:43","modified_gmt":"2024-02-28T23:25:43","slug":"double-trouble-at-chromosome-ends-new-study-alters-our-understanding-of-telomere-biology","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/02\/double-trouble-at-chromosome-ends-new-study-alters-our-understanding-of-telomere-biology","title":{"rendered":"Double trouble at chromosome ends: New study alters our understanding of telomere biology"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/double-trouble-at-chromosome-ends-new-study-alters-our-understanding-of-telomere-biology2.jpg\"><\/a><\/p>\n<p>Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres that protect the ends of chromosomes should have been growing shorter with each round of replication, a phenomenon known as the end-replication problem.<\/p>\n<p>But a solution was forthcoming: Liz Blackburn and Carol Greider discovered telomerase, an enzyme that adds the telomeric repeats to the ends of chromosomes. \u201cCase closed, everybody thought,\u201d says Rockefeller\u2019s Titia de Lange.<\/p>\n<p>Now, research <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-07137-1\">published<\/a> in <i>Nature<\/i> suggests that there are two end-replication problems, not one. Further, telomerase is only part of the solution\u2014cells also use the CST\u2013Pol\u03b1-primase complex, which has been extensively studied in de Lange\u2019s laboratory.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres that protect the ends of chromosomes should have been growing shorter with each round of replication, a phenomenon known as the end-replication problem. [\u2026]<\/p>\n","protected":false},"author":396,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-183947","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/183947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/396"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=183947"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/183947\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=183947"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=183947"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=183947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}