{"id":182977,"date":"2024-02-17T21:46:39","date_gmt":"2024-02-18T03:46:39","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/02\/donor-recipient-enhancement-of-memory-in-rat-hippocampus"},"modified":"2024-02-17T21:46:39","modified_gmt":"2024-02-18T03:46:39","slug":"donor-recipient-enhancement-of-memory-in-rat-hippocampus","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/02\/donor-recipient-enhancement-of-memory-in-rat-hippocampus","title":{"rendered":"Donor\/recipient enhancement of memory in rat hippocampus"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/donor-recipient-enhancement-of-memory-in-rat-hippocampus3.jpg\"><\/a><\/p>\n<p>The critical role of the mammalian hippocampus in the formation, translation and retrieval of <i>memory<\/i> has been documented over many decades. There are many theories of how the hippocampus operates to encode events and a precise mechanism was recently identified in rats performing a short-term <i>memory<\/i> task which demonstrated that successful information encoding was promoted via specific patterns of activity generated within ensembles of hippocampal neurons. In the study presented here, these \u201crepresentations\u201d were extracted via a customized non-linear multi-input multi-output (MIMO) mathematical model which allowed prediction of successful performance on specific trials within the testing session. A unique feature of this characterization was demonstrated when successful information encoding patterns were derived online from well-trained \u201c<i>donor<\/i>\u201d animals during difficult long-delay trials and delivered via online electrical stimulation to synchronously tested na\u00efve \u201c<i>recipient<\/i>\u201d animals never before exposed to the delay feature of the task. By transferring such model-derived trained (<i>donor<\/i>) animal hippocampal firing patterns via stimulation to coupled na\u00efve <i>recipient<\/i> animals, their task performance was facilitated in a direct \u201c<i>donor\u2013<i>recipient<\/i><\/i>\u201d manner. This provides the basis for utilizing extracted appropriate neural information from one brain to induce, recover, or enhance <i>memory<\/i> related processing in the brain of another subject.<\/p>\n<p>To understand the neural basis of <i>memory<\/i>, several features of the context in which the memories occur and are utilized, and the functional aspects of the brain areas involved, need to be identified and controlled (Hampson et al., 2008; Eichenbaum and Fortin, 2009). In prior studies we achieved both of these important contingencies as well as overcoming possible alternative interpretations of the relationship between recorded hippocampal ensemble activity and the behavioral task in which short-term <i>memory<\/i> formation is necessary (Deadwyler and Hampson, 2006; Deadwyler et al., 2007), and developing an effective mathematical\/operational model for online prediction of CA1 hippocampal cell activity from simultaneously recorded input firing patterns from synaptically connected CA3 neurons (Song et al., 2009; Berger et al., 2011; Hampson et al., 2011).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The critical role of the mammalian hippocampus in the formation, translation and retrieval of memory has been documented over many decades. There are many theories of how the hippocampus operates to encode events and a precise mechanism was recently identified in rats performing a short-term memory task which demonstrated that successful information encoding was promoted [\u2026]<\/p>\n","protected":false},"author":661,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2229,47],"tags":[],"class_list":["post-182977","post","type-post","status-publish","format-standard","hentry","category-mathematics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/182977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/661"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=182977"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/182977\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=182977"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=182977"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=182977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}