{"id":182803,"date":"2024-02-16T07:22:23","date_gmt":"2024-02-16T13:22:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/02\/study-reveals-how-cells-keep-telomerase-in-check"},"modified":"2024-02-16T07:22:23","modified_gmt":"2024-02-16T13:22:23","slug":"study-reveals-how-cells-keep-telomerase-in-check","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/02\/study-reveals-how-cells-keep-telomerase-in-check","title":{"rendered":"Study reveals how cells keep telomerase in check"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/study-reveals-how-cells-keep-telomerase-in-check2.jpg\"><\/a><\/p>\n<p>The natural ends of chromosomes appear alarmingly like broken DNA, much as a snapped spaghetti strand is difficult to distinguish from its intact counterparts. Yet every cell in our bodies must have a way of differentiating between the two because the best way to protect the healthy end of a chromosome also happens to be the worst way to repair damaged DNA.<\/p>\n<p>Consider the <a href=\"https:\/\/phys.org\/tags\/enzyme+telomerase\/\" rel=\"tag\" class=\"\">enzyme telomerase<\/a>, which is responsible for maintaining protective telomeres at the natural ends of chromosomes. Were telomerase to seal off a broken strand of DNA with a <a href=\"https:\/\/phys.org\/tags\/telomere\/\" rel=\"tag\" class=\"\">telomere<\/a>, it would prevent further repair of that break and delete essential genes.<\/p>\n<p>Now, a new study in <i>Science<\/i> <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adg3224\">describes<\/a> how cells avoid such mishaps. These findings show that telomerase can indeed run amok, adding telomeres to damaged DNA, and would do so were it not for the ATR kinase, a key enzyme that responds to DNA damage.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The natural ends of chromosomes appear alarmingly like broken DNA, much as a snapped spaghetti strand is difficult to distinguish from its intact counterparts. Yet every cell in our bodies must have a way of differentiating between the two because the best way to protect the healthy end of a chromosome also happens to be [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-182803","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/182803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=182803"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/182803\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=182803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=182803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=182803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}