{"id":182383,"date":"2024-02-09T11:32:37","date_gmt":"2024-02-09T17:32:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/02\/faulty-dna-disposal-system-found-to-cause-inflammation"},"modified":"2024-02-09T11:32:37","modified_gmt":"2024-02-09T17:32:37","slug":"faulty-dna-disposal-system-found-to-cause-inflammation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/02\/faulty-dna-disposal-system-found-to-cause-inflammation","title":{"rendered":"Faulty DNA disposal system found to cause inflammation"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/faulty-dna-disposal-system-found-to-cause-inflammation2.jpg\"><\/a><\/p>\n<p>Cells in the human body contain power-generating mitochondria, each with their own mtDNA\u2014a unique set of genetic instructions entirely separate from the cell\u2019s nuclear DNA that mitochondria use to create life-giving energy. When mtDNA remains where it belongs (inside of mitochondria), it sustains both mitochondrial and cellular health\u2014but when it goes where it doesn\u2019t belong, it can initiate an immune response that promotes inflammation.<\/p>\n<p>Now, Salk scientists and collaborators at UC San Diego have discovered a novel mechanism used to remove improperly functioning mtDNA from inside to outside the mitochondria. When this happens, the mtDNA gets flagged as foreign DNA and activates a <a href=\"https:\/\/medicalxpress.com\/tags\/cellular+pathway\/\" rel=\"tag\" class=\"\">cellular pathway<\/a> normally used to promote <a href=\"https:\/\/medicalxpress.com\/tags\/inflammation\/\" rel=\"tag\" class=\"\">inflammation<\/a> to rid the cell of pathogens, like viruses.<\/p>\n<p>The findings, published in <a href=\"https:\/\/www.nature.com\/articles\/s41556-023-01343-1\">Nature Cell Biology<\/a>, offer many new targets for therapeutics to disrupt the inflammatory pathway and therefore mitigate inflammation during aging and diseases, like lupus or rheumatoid arthritis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cells in the human body contain power-generating mitochondria, each with their own mtDNA\u2014a unique set of genetic instructions entirely separate from the cell\u2019s nuclear DNA that mitochondria use to create life-giving energy. When mtDNA remains where it belongs (inside of mitochondria), it sustains both mitochondrial and cellular health\u2014but when it goes where it doesn\u2019t belong, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,269,873],"tags":[],"class_list":["post-182383","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-life-extension","category-nuclear-energy"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/182383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=182383"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/182383\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=182383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=182383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=182383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}