{"id":181917,"date":"2024-02-02T22:23:27","date_gmt":"2024-02-03T04:23:27","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2024\/02\/gene-editing-precisely-repairs-immune-cells"},"modified":"2024-02-02T22:23:27","modified_gmt":"2024-02-03T04:23:27","slug":"gene-editing-precisely-repairs-immune-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2024\/02\/gene-editing-precisely-repairs-immune-cells","title":{"rendered":"Gene editing precisely repairs immune cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/gene-editing-precisely-repairs-immune-cells2.jpg\"><\/a><\/p>\n<p>Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbr\u00fcck Center now <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.adi0042\">report<\/a> in Science Immunology.<\/p>\n<p>Familial hemophagocytic lymphohistiocytosis (FHL) is a rare disease of the immune system that usually occurs in infants and <a href=\"https:\/\/medicalxpress.com\/tags\/young+children\/\" rel=\"tag\" class=\"\">young children<\/a> under the age of 18 months. The condition is severe and has a high mortality rate. It is caused by various gene mutations that prevent cytotoxic T cells from functioning normally. These are a group of immune cells that kill virus\u2013<a href=\"https:\/\/medicalxpress.com\/tags\/infected+cells\/\" rel=\"tag\" class=\"\">infected cells<\/a> or otherwise altered cells.<\/p>\n<p>If a child with FHL contracts a virus\u2014such as the Epstein-Barr virus (EBV), but also other viruses\u2014the cytotoxic T cells cannot eliminate the infected cells. Instead, the immune response gets out of control. This leads to a cytokine storm and an excessive inflammatory reaction that affects the entire organism.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Some hereditary genetic defects cause an exaggerated immune response that can be fatal. Using the CRISPR-Cas9 gene-editing tool, such defects can be corrected, thus normalizing the immune response, as researchers led by Klaus Rajewsky from the Max Delbr\u00fcck Center now report in Science Immunology. Familial hemophagocytic lymphohistiocytosis (FHL) is a rare disease of the immune [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,412],"tags":[],"class_list":["post-181917","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/181917","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=181917"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/181917\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=181917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=181917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=181917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}